Fine-Gray proportional hazard regression for high-risk clonal evolution
| . | Univariate model . | Multivariate model 1 . | Multivariate model 2 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age ≥40 y | 4.00 | 1.90-8.40 | .00026 | 4.87 | 2.16-11.0 | .00014 | 4.73 | 2.10-10.7 | .00018 |
| HLA-B*14:02 genotype | 2.83 | 1.32-6.10 | .0077 | 2.47 | 1.01-6.05 | .048 | |||
| HLA loss | 3.68 | 1.77-7.66 | .00050 | 2.70 | 1.20-6.08 | .017 | |||
| Combined HLA risk† | 4.44 | 2.04-9.68 | .00018 | 4.26 | 1.02-9.48 | .00038 | |||
| . | Univariate model . | Multivariate model 1 . | Multivariate model 2 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age ≥40 y | 4.00 | 1.90-8.40 | .00026 | 4.87 | 2.16-11.0 | .00014 | 4.73 | 2.10-10.7 | .00018 |
| HLA-B*14:02 genotype | 2.83 | 1.32-6.10 | .0077 | 2.47 | 1.01-6.05 | .048 | |||
| HLA loss | 3.68 | 1.77-7.66 | .00050 | 2.70 | 1.20-6.08 | .017 | |||
| Combined HLA risk† | 4.44 | 2.04-9.68 | .00018 | 4.26 | 1.02-9.48 | .00038 | |||
Presence of HLA loss or HLA-B*14:02 genotype.