HLA allele frequencies in patients with AA and healthy individuals in the NMDP dataset
| HLA allele . | Allele frequency, % (phenotype frequency, %) . | Odds ratio of allele frequency (95% CI) . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| White . | African American . | Hispanic . | Asian . | ||||||
| AA n = 275 . | Control n = 3 912 440 . | AA n = 120 . | Control n = 505 250 . | AA n = 109 . | Control n = 712 764 . | AA n = 35 . | Control n = 568 597 . | ||
| HLA-B*14:02 | 7.3 (12.7) | 2.7 (5.4) | 5.0 (10.0) | 2.2 (4.3) | 7.8 (14.7) | 4.2 (8.3) | 0.0 (0) | 0.2 (0.3) | 2.44 (1.91-3.12) |
| HLA-B*40:02 | 2.4 (4.7) | 1.3 (2.7) | 0.4 (0.8) | 0.3 (0.7) | 7.3 (13.8) | 5.0 (9.7) | 11.4 (20.0) | 2.4 (4.8) | 1.88 (1.36-2.61) |
| HLA-B*07:02 | 17.6 (32.4) | 12.5 (23.4) | 8.8 (15.8) | 7.3 (14.0) | 8.3 (16.5) | 5.8 (11.2) | 1.4 (2.9) | 2.9 (5.8) | 1.42 (1.19-1.70) |
| HLA-A*02:01 | 28.4 (50.5) | 27.2 (46.9) | 12.9 (24.2) | 12.2 (23.0) | 17.0 (29.4) | 21.0 (37.5) | 7.1 (11.4) | 8.4 (16.2) | 0.99 (0.86-1.15) |
| HLA-B*08:01 | 9.5 (17.8) | 10.6 (20.0) | 3.8 (7.5) | 3.7 (7.2) | 4.6 (9.2) | 4.2 (8.2) | 0 (0) | 1.8 (3.5) | 0.92 (0.72-1.17) |
| HLA allele . | Allele frequency, % (phenotype frequency, %) . | Odds ratio of allele frequency (95% CI) . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| White . | African American . | Hispanic . | Asian . | ||||||
| AA n = 275 . | Control n = 3 912 440 . | AA n = 120 . | Control n = 505 250 . | AA n = 109 . | Control n = 712 764 . | AA n = 35 . | Control n = 568 597 . | ||
| HLA-B*14:02 | 7.3 (12.7) | 2.7 (5.4) | 5.0 (10.0) | 2.2 (4.3) | 7.8 (14.7) | 4.2 (8.3) | 0.0 (0) | 0.2 (0.3) | 2.44 (1.91-3.12) |
| HLA-B*40:02 | 2.4 (4.7) | 1.3 (2.7) | 0.4 (0.8) | 0.3 (0.7) | 7.3 (13.8) | 5.0 (9.7) | 11.4 (20.0) | 2.4 (4.8) | 1.88 (1.36-2.61) |
| HLA-B*07:02 | 17.6 (32.4) | 12.5 (23.4) | 8.8 (15.8) | 7.3 (14.0) | 8.3 (16.5) | 5.8 (11.2) | 1.4 (2.9) | 2.9 (5.8) | 1.42 (1.19-1.70) |
| HLA-A*02:01 | 28.4 (50.5) | 27.2 (46.9) | 12.9 (24.2) | 12.2 (23.0) | 17.0 (29.4) | 21.0 (37.5) | 7.1 (11.4) | 8.4 (16.2) | 0.99 (0.86-1.15) |
| HLA-B*08:01 | 9.5 (17.8) | 10.6 (20.0) | 3.8 (7.5) | 3.7 (7.2) | 4.6 (9.2) | 4.2 (8.2) | 0 (0) | 1.8 (3.5) | 0.92 (0.72-1.17) |
Allele frequency is copy number/2n. The phenotype frequency in the NMDP donors was estimated by the equation of (phenotype frequency) = 1 - (1 - [allele frequency])2.