ISTH diagnostic algorithm for the diagnosis of overt DIC
| Parameter/result . | Score* . |
|---|---|
| Underlying disease | |
| No | — |
| Yes; proceed | — |
| Platelet count | |
| >100 ×109/L | 0 |
| <100 ×109/L but >50 ×109/L | 1 |
| <50 ×109/L | 2 |
| Prolonged PT | |
| <3 s | 0 |
| >3 s but <6 s | 1 |
| >6 s | 2 |
| Elevated fibrin-related marker (eg, soluble fibrin monomer/fibrin degradation products) | |
| No increase | 0 |
| Moderate increase | 2 |
| Strong increase | 3 |
| Fibrinogen level | |
| >1.0 g/L | 0 |
| <1.0 g/L | 1 |
| Parameter/result . | Score* . |
|---|---|
| Underlying disease | |
| No | — |
| Yes; proceed | — |
| Platelet count | |
| >100 ×109/L | 0 |
| <100 ×109/L but >50 ×109/L | 1 |
| <50 ×109/L | 2 |
| Prolonged PT | |
| <3 s | 0 |
| >3 s but <6 s | 1 |
| >6 s | 2 |
| Elevated fibrin-related marker (eg, soluble fibrin monomer/fibrin degradation products) | |
| No increase | 0 |
| Moderate increase | 2 |
| Strong increase | 3 |
| Fibrinogen level | |
| >1.0 g/L | 0 |
| <1.0 g/L | 1 |
Adapted from Taylor et al.1
If ≥5, compatible with overt DIC, repeat scoring daily; if <5, suggestive (not affirmative) of nonovert DIC, repeat next in 1 to 2 d.