Development of prognostic scoring system
| Variable . | HR (95% CI) . | P . | Points . |
|---|---|---|---|
| AML | |||
| Age, y | .0031 | ||
| ≥3 | 1.00 | 0 | |
| <3 | 1.45 (1.13-1.86) | 2 | |
| Disease status | <.0001 | ||
| 1st complete remission MRD− | 1.00 | 0 | |
| 1st complete remission MRD+ | 1.08 (0.76-1.55) | 0 | |
| 2nd complete remission MRD− | 0.89 (0.63-1.26) | 0 | |
| 2nd complete remission MRD+ | 1.81 (1.18-2.77) | 3 | |
| Not in remission | 2.55 (1.87-3.46) | 5 | |
| Cytogenetic risk | .0083 | ||
| Favorable | 1.00 | 0 | |
| Intermediate/poor | 2.37 (1.36-4.11) | 5 | |
| ALL | |||
| Age, y | .0042 | ||
| ≥2 | 1.00 | 0 | |
| <2 | 2.05 (1.25-3.36) | 3 | |
| Disease status | .0001 | ||
| 1st complete remission MRD− | 1.00 | 0 | |
| 1st complete remission MRD+ | 1.04 (0.67-1.62) | 0 | |
| ≥2nd complete remission MRD− | 1.52 (1.09-2.11) | 2 | |
| ≥2nd complete remission MRD+ | 2.17 (1.46-3.21) | 4 | |
| Not in remission | 2.57 (1.52-4.33) | 5 |
| Variable . | HR (95% CI) . | P . | Points . |
|---|---|---|---|
| AML | |||
| Age, y | .0031 | ||
| ≥3 | 1.00 | 0 | |
| <3 | 1.45 (1.13-1.86) | 2 | |
| Disease status | <.0001 | ||
| 1st complete remission MRD− | 1.00 | 0 | |
| 1st complete remission MRD+ | 1.08 (0.76-1.55) | 0 | |
| 2nd complete remission MRD− | 0.89 (0.63-1.26) | 0 | |
| 2nd complete remission MRD+ | 1.81 (1.18-2.77) | 3 | |
| Not in remission | 2.55 (1.87-3.46) | 5 | |
| Cytogenetic risk | .0083 | ||
| Favorable | 1.00 | 0 | |
| Intermediate/poor | 2.37 (1.36-4.11) | 5 | |
| ALL | |||
| Age, y | .0042 | ||
| ≥2 | 1.00 | 0 | |
| <2 | 2.05 (1.25-3.36) | 3 | |
| Disease status | .0001 | ||
| 1st complete remission MRD− | 1.00 | 0 | |
| 1st complete remission MRD+ | 1.04 (0.67-1.62) | 0 | |
| ≥2nd complete remission MRD− | 1.52 (1.09-2.11) | 2 | |
| ≥2nd complete remission MRD+ | 2.17 (1.46-3.21) | 4 | |
| Not in remission | 2.57 (1.52-4.33) | 5 |