Baseline characteristics and blood counts
| . | Case 1 . | Case 2 . | Controls* (n = 48.775) . | Reference range† . |
|---|---|---|---|---|
| Age | 56 | 63 | 55-65 | |
| Sex | Female | Female | Females | |
| White blood cell (leukocyte) count ×109 cells/L | 6.84 | 5.17 | 6.58 (4.1-10.65) | 3.53-9.57 |
| Red blood cell (erythrocyte) count ×1012 cells/L | 3.35‡ | 3.94 | 4.35 (3.72-5) | 3.96-5.50 |
| Hemoglobin concentration, g/dL | 11.89 | 13.41 | 13.6 (11.81-15.33) | 12.14-16.27 |
| Hematocrit percentage, % | 35.05 | 39.62 | 39.59 (34.3-44.71) | 35.39-47.19 |
| Mean corpuscular volume, fL | 104.5‡ | 100.5‡ | 91.16 (82.8-99.1) | 76.9-94.7 |
| Mean corpuscular hemoglobin, pg | 35.44‡ | 34 | 31.37 (28-34.38) | 25.69-32.95 |
| Mean corpuscular hemoglobin concentration, g/dL | 33.92 | 33.84 | 34.33 (32.77-36.23) | 33.34-35.47 |
| Red blood cell (erythrocyte) distribution width, % | 16.06‡ | 13.4 | 13.36 (12.2-15.47) | 12.09-15.19 |
| Platelet count, 109 cells/L | 206.9 | 241.5 | 259 (164-391) | 169.06-397.10 |
| Plateletcrit, % | 0.16 | 0.18 | 0.24 (0.16-0.34) | Not stated |
| Mean platelet (thrombocyte) volume, fL | 7.66 | 7.45‡ | 9.2 (7.58-11.84) | 7.54-11.24 |
| Platelet distribution width, % | 16.54 | 16.21 | 16.38 (15.6-17.6) | Not stated |
| Lymphocyte count, 109 cells/L | 3.86 | 2.75 | 1.97 (1.04-3.45) | 0.65-4.25 |
| Monocyte count, 109 cells/L | 0.67 | 0.27 | 0.41 (0.2-0.79) | 0.17-1.21 |
| Neutrophil count, 109 cells/L | 2.09 | 2.1 | 3.9 (2.1-7.15) | 1.47-7.06 |
| Eosinophil count, 109 cells/L | 0.21 | 0.03 | 0.12 (0-0.48) | 0.03-0.77 |
| Basophil count, 109 cells/L | 0.02 | 0.02 | 0.02 (0-0.12) | 0.01-0.13 |
| Reticulocyte count, 1012 cells/L | 0.08 | 0.11 | 0.05 (0.02-0.11) | 0.02-0.11 |
| . | Case 1 . | Case 2 . | Controls* (n = 48.775) . | Reference range† . |
|---|---|---|---|---|
| Age | 56 | 63 | 55-65 | |
| Sex | Female | Female | Females | |
| White blood cell (leukocyte) count ×109 cells/L | 6.84 | 5.17 | 6.58 (4.1-10.65) | 3.53-9.57 |
| Red blood cell (erythrocyte) count ×1012 cells/L | 3.35‡ | 3.94 | 4.35 (3.72-5) | 3.96-5.50 |
| Hemoglobin concentration, g/dL | 11.89 | 13.41 | 13.6 (11.81-15.33) | 12.14-16.27 |
| Hematocrit percentage, % | 35.05 | 39.62 | 39.59 (34.3-44.71) | 35.39-47.19 |
| Mean corpuscular volume, fL | 104.5‡ | 100.5‡ | 91.16 (82.8-99.1) | 76.9-94.7 |
| Mean corpuscular hemoglobin, pg | 35.44‡ | 34 | 31.37 (28-34.38) | 25.69-32.95 |
| Mean corpuscular hemoglobin concentration, g/dL | 33.92 | 33.84 | 34.33 (32.77-36.23) | 33.34-35.47 |
| Red blood cell (erythrocyte) distribution width, % | 16.06‡ | 13.4 | 13.36 (12.2-15.47) | 12.09-15.19 |
| Platelet count, 109 cells/L | 206.9 | 241.5 | 259 (164-391) | 169.06-397.10 |
| Plateletcrit, % | 0.16 | 0.18 | 0.24 (0.16-0.34) | Not stated |
| Mean platelet (thrombocyte) volume, fL | 7.66 | 7.45‡ | 9.2 (7.58-11.84) | 7.54-11.24 |
| Platelet distribution width, % | 16.54 | 16.21 | 16.38 (15.6-17.6) | Not stated |
| Lymphocyte count, 109 cells/L | 3.86 | 2.75 | 1.97 (1.04-3.45) | 0.65-4.25 |
| Monocyte count, 109 cells/L | 0.67 | 0.27 | 0.41 (0.2-0.79) | 0.17-1.21 |
| Neutrophil count, 109 cells/L | 2.09 | 2.1 | 3.9 (2.1-7.15) | 1.47-7.06 |
| Eosinophil count, 109 cells/L | 0.21 | 0.03 | 0.12 (0-0.48) | 0.03-0.77 |
| Basophil count, 109 cells/L | 0.02 | 0.02 | 0.02 (0-0.12) | 0.01-0.13 |
| Reticulocyte count, 1012 cells/L | 0.08 | 0.11 | 0.05 (0.02-0.11) | 0.02-0.11 |
Ranges of blood counts in female UKBB participants aged 55-65 y without a hematological malignancy diagnosis. Values are represented as median (2.5 percentile to 97.5 percentile).
Ranges provided by the manufacturer. Values represent the 2.5 to 97.5 percentile range.
Value outside the 2.5 to 97.5 percentile range of healthy controls and the quoted normal reference range of the automated hematology analyzer.