Baseline characteristics and pregnancy outcomes of women with sickle cell disease in the post intervention and sustainability periods
| Patient characteristic . | Postintervention period: 13 mo (n = 90) . | Sustainability period: 43 mo (n = 342) . | P* . |
|---|---|---|---|
| Age, n (%), y | |||
| <20 | 4 (4.4) | 12 (3.5) | .477 |
| 20-34 | 73 (81.1) | 262 (76.6) | |
| ≥35 | 13 (14.4) | 68 (19.9) | |
| Mean age (SD), y | 28.8 (4.9) | 29.6 (5.2) | .192 |
| Phenotype, n (%) | |||
| HbSS | 35 (38.9) | 139 (40.6) | .763 |
| HbSC | 55 (61.1) | 203 ((59.4) | |
| Parity, n (%) | |||
| 0-1 | 71 (78.9) | 254 (74.3) | .366 |
| 2-5 | 19 (21.1) | 88 (25.7) | |
| Gestational age at enrollment, n (%) | |||
| First trimester (up to 13 wk) | 17 (18.9) | 41 (12.0) | .096 |
| Second trimester (13 wk 1 d up to 26 wk) | 37 (41.1) | 126 (36.8) | |
| Third trimester (26 wk 1 d up to 40 wk) | 36 (40.0) | 175 (51.2) | |
| Mean gestational age at enrollment (SD), wk | 23.9 (8.6) | 25.2 (8.8) | .190 |
| Gestational age at delivery (n = 430) | |||
| Extreme preterm (<28 wk gestation) | 3 (3.4) | 14 (4.1) | .922 |
| Very preterm (28 to 32 wk gestation) | 2 (2.2) | 5 (1.5) | |
| Moderate preterm (32 wk 1 d to 34 wk gestation) | 5 (5.6) | 20 (5.9) | |
| Late preterm (34 wk 1 d to 37 wk gestation) | 12 (13.5) | 56 (16.4) | |
| Term (37 wk 1 d to 42 wk gestation) | 67 (75.3) | 246 (72.1) | |
| Fetal outcome, n (%) | |||
| Spontaneous abortion | 3 (3.3) | 10 (2.9) | .969 |
| Intrauterine fetal death | 2 (2.2) | 8 (2.3) | |
| Stillbirth | 0 (0.0) | 1 (0.3) | |
| Died in utero with mother | 0 (0.0) | 2 (0.6) | |
| Alive | 85 (94.5) | 320 (93.6) | |
| Unknown | 0 (0.0) | 1 (0.3) | |
| Type of delivery, n (%) (n = 426) | |||
| Caesarean | 42 (46.7) | 212 (63.1) | .012 |
| Vaginal | 45 (50.0) | 112 (33.3) | |
| Not delivered† | 3 (3.3) | 12 (3.6) | |
| Perinatal outcome | |||
| Perinatal deaths, n (%) | 2 (2.2) | 9 (2.7) | 1.000 |
| Perinatal deaths per 1000 total births | 23.0 | 27.4 | |
| Maternal outcome | |||
| Maternal deaths, n (%) | 1 (1.1) | 9 (2.6) | .695 |
| Maternal deaths per 100 000 live births | 1,176 | 2,812 | |
| Causes of maternal death | |||
| Indirect obstetric (SCD-related) deaths | |||
| Acute chest syndrome (ACS) | 0 | 6 | |
| Venous thromboembolism (VTE) | 1 | 1 | |
| Congestive cardiac failure (CCF) | 0 | 1 | |
| Direct obstetric deaths | |||
| Obstetric hemorrhage | 0 | 1 | |
| Patient characteristic . | Postintervention period: 13 mo (n = 90) . | Sustainability period: 43 mo (n = 342) . | P* . |
|---|---|---|---|
| Age, n (%), y | |||
| <20 | 4 (4.4) | 12 (3.5) | .477 |
| 20-34 | 73 (81.1) | 262 (76.6) | |
| ≥35 | 13 (14.4) | 68 (19.9) | |
| Mean age (SD), y | 28.8 (4.9) | 29.6 (5.2) | .192 |
| Phenotype, n (%) | |||
| HbSS | 35 (38.9) | 139 (40.6) | .763 |
| HbSC | 55 (61.1) | 203 ((59.4) | |
| Parity, n (%) | |||
| 0-1 | 71 (78.9) | 254 (74.3) | .366 |
| 2-5 | 19 (21.1) | 88 (25.7) | |
| Gestational age at enrollment, n (%) | |||
| First trimester (up to 13 wk) | 17 (18.9) | 41 (12.0) | .096 |
| Second trimester (13 wk 1 d up to 26 wk) | 37 (41.1) | 126 (36.8) | |
| Third trimester (26 wk 1 d up to 40 wk) | 36 (40.0) | 175 (51.2) | |
| Mean gestational age at enrollment (SD), wk | 23.9 (8.6) | 25.2 (8.8) | .190 |
| Gestational age at delivery (n = 430) | |||
| Extreme preterm (<28 wk gestation) | 3 (3.4) | 14 (4.1) | .922 |
| Very preterm (28 to 32 wk gestation) | 2 (2.2) | 5 (1.5) | |
| Moderate preterm (32 wk 1 d to 34 wk gestation) | 5 (5.6) | 20 (5.9) | |
| Late preterm (34 wk 1 d to 37 wk gestation) | 12 (13.5) | 56 (16.4) | |
| Term (37 wk 1 d to 42 wk gestation) | 67 (75.3) | 246 (72.1) | |
| Fetal outcome, n (%) | |||
| Spontaneous abortion | 3 (3.3) | 10 (2.9) | .969 |
| Intrauterine fetal death | 2 (2.2) | 8 (2.3) | |
| Stillbirth | 0 (0.0) | 1 (0.3) | |
| Died in utero with mother | 0 (0.0) | 2 (0.6) | |
| Alive | 85 (94.5) | 320 (93.6) | |
| Unknown | 0 (0.0) | 1 (0.3) | |
| Type of delivery, n (%) (n = 426) | |||
| Caesarean | 42 (46.7) | 212 (63.1) | .012 |
| Vaginal | 45 (50.0) | 112 (33.3) | |
| Not delivered† | 3 (3.3) | 12 (3.6) | |
| Perinatal outcome | |||
| Perinatal deaths, n (%) | 2 (2.2) | 9 (2.7) | 1.000 |
| Perinatal deaths per 1000 total births | 23.0 | 27.4 | |
| Maternal outcome | |||
| Maternal deaths, n (%) | 1 (1.1) | 9 (2.6) | .695 |
| Maternal deaths per 100 000 live births | 1,176 | 2,812 | |
| Causes of maternal death | |||
| Indirect obstetric (SCD-related) deaths | |||
| Acute chest syndrome (ACS) | 0 | 6 | |
| Venous thromboembolism (VTE) | 1 | 1 | |
| Congestive cardiac failure (CCF) | 0 | 1 | |
| Direct obstetric deaths | |||
| Obstetric hemorrhage | 0 | 1 | |