Table 1.

Costs and clinical variables included in the model

Model variableCPX-3517 + 3Ref.
Base-case scenarioRangeBase-case scenarioRange
Treatment patterns      
 Probability of requiring reinduction 0.31 0.16-0.47 0.34 0.17-0.51 3  
 Probability of receiving cycle 1 of consolidation 0.32 0.16-0.48 0.21 0.11-0.32 3  
 Probability of receiving consolidation 1 as inpatient 0.49 0.25-0.74 0.94 0.50-1.00 3  
 Probability of receiving consolidation 1 as outpatient 0.51 0.26-0.77 0.06 0.03-0.09 3  
 Probability of receiving cycle 2 of consolidation 0.15 0.08-0.22 0.08 0.04-0.12 3  
 Probability of receiving consolidation 2 as inpatient 0.39 0.20-0.59 1.0 N/A 3  
 Probability of receiving consolidation 2 as outpatient 0.61 0.31-0.92 0 N/A 3  
 Probability to proceed to allo-HCT 0.34 0.17-0.51 0.25 0.13-0.38 1  
 Probability to receive salvage chemotherapy 0.23 0.12-0.35 0.23 0.12-0.35 20  
 Probability to receive LIT at time of relapse 0.33 0.17-0.50 0.33 0.17-0.50 20  
 Probability to proceed to hospice/BSC 0.44 0.22-0.66 0.44 0.22-0.66 20  
Costs      
 Cost of inpatient induction     6,7  
  Baseline AML induction cost for 1 cycle $68 983 $34 492-103 475 $68 983 $34 392-103 475  
  Baseline AML induction cost for 2 cycles $134 484 $67 242-201 726 $134 484 $67 242-201 726  
  CPX-351 drug cost-induction $53 484 $26 742-80 226 N/A   
  CPX-351 drug cost-re-induction $35 656 $17 828-53 484 N/A   
 Cost of inpatient consolidation per cycle     6,7  
  Baseline AML consolidation cost $30 762 $15 381-46 143 $30 762 $15 381-46 143  
  CPX-351 drug cost: consolidation $35 656 $17 828-53 484 N/A   
 Cost of outpatient consolidation per cycle     1,6,7  
  Baseline outpatient consolidation cost $6 189 $3 095-9 284 $6 189 $3 095-9 284  
  CPX-351 drug cost per dose (2 doses) $35 656 $17 828-53 484 N/A   
 Cost of salvage chemotherapy $153 737 $76 869-230 606 $153 737 $76 869-230 606 8  
 Cost of LIT (cycle) $10 522 $5 261-15 783 $10 522 $5 261-15 783 9  
 Number of other lower-intensity salvage therapy cycles 6 3-9 cycles 6 3-9 cycles 9  
 Cost of allo-HCT $145 892 $72 946-218 838 $145 892 $72 946-218 838 6  
 Cost of office visit $131 $66-197 $131 $66-197 21  
 Number of office visits (per mo) 10.5 5-15 10.5 5-15 6  
 Cost of hospice care (mo) $1 129 $565-1 694 $1 129 $565-1 694 11  
 Cost of supportive care (mo) $3 882 $1 941-5 823 $3 882 $1 941-5 823 10  
 Cost of terminal care $8 890 $4 445-13 335 $8 890 $4 445-13 335 6  
 Unplanned admission     6  
  Likelihood of unplanned admission 0.4/mo 0.2-0.6/mo 0.4/mo 0.2-0.6/mo  
  Costs per episode $17 220 $8 610-25 830 $17 220 $8 610-25 830  
 ED visits     6  
  Likelihood of ED visit 0.11/mo 0.06-0.17/mo 0.11/mo 0.06-0.17/mo  
  Costs per episode $1 030 $515-1 545 $1 030 $515-1 545  
Utilities      
 Utility during induction (months 0-2) 0.44 0.40-0.48 0.40 0.36-0.44 13  
 Utility during temporary remission (3-5 mo) 0.66 0.60-0.72 0.66 0.60-0.72 13  
 Utility during long-term remission (≥6 mo) 0.82 0.74-0.90 0.82 0.74-0.90 14  
 Utility during disease relapse 0.53 0.48-0.58 0.53 0.48-0.53 14  
Model variableCPX-3517 + 3Ref.
Base-case scenarioRangeBase-case scenarioRange
Treatment patterns      
 Probability of requiring reinduction 0.31 0.16-0.47 0.34 0.17-0.51 3  
 Probability of receiving cycle 1 of consolidation 0.32 0.16-0.48 0.21 0.11-0.32 3  
 Probability of receiving consolidation 1 as inpatient 0.49 0.25-0.74 0.94 0.50-1.00 3  
 Probability of receiving consolidation 1 as outpatient 0.51 0.26-0.77 0.06 0.03-0.09 3  
 Probability of receiving cycle 2 of consolidation 0.15 0.08-0.22 0.08 0.04-0.12 3  
 Probability of receiving consolidation 2 as inpatient 0.39 0.20-0.59 1.0 N/A 3  
 Probability of receiving consolidation 2 as outpatient 0.61 0.31-0.92 0 N/A 3  
 Probability to proceed to allo-HCT 0.34 0.17-0.51 0.25 0.13-0.38 1  
 Probability to receive salvage chemotherapy 0.23 0.12-0.35 0.23 0.12-0.35 20  
 Probability to receive LIT at time of relapse 0.33 0.17-0.50 0.33 0.17-0.50 20  
 Probability to proceed to hospice/BSC 0.44 0.22-0.66 0.44 0.22-0.66 20  
Costs      
 Cost of inpatient induction     6,7  
  Baseline AML induction cost for 1 cycle $68 983 $34 492-103 475 $68 983 $34 392-103 475  
  Baseline AML induction cost for 2 cycles $134 484 $67 242-201 726 $134 484 $67 242-201 726  
  CPX-351 drug cost-induction $53 484 $26 742-80 226 N/A   
  CPX-351 drug cost-re-induction $35 656 $17 828-53 484 N/A   
 Cost of inpatient consolidation per cycle     6,7  
  Baseline AML consolidation cost $30 762 $15 381-46 143 $30 762 $15 381-46 143  
  CPX-351 drug cost: consolidation $35 656 $17 828-53 484 N/A   
 Cost of outpatient consolidation per cycle     1,6,7  
  Baseline outpatient consolidation cost $6 189 $3 095-9 284 $6 189 $3 095-9 284  
  CPX-351 drug cost per dose (2 doses) $35 656 $17 828-53 484 N/A   
 Cost of salvage chemotherapy $153 737 $76 869-230 606 $153 737 $76 869-230 606 8  
 Cost of LIT (cycle) $10 522 $5 261-15 783 $10 522 $5 261-15 783 9  
 Number of other lower-intensity salvage therapy cycles 6 3-9 cycles 6 3-9 cycles 9  
 Cost of allo-HCT $145 892 $72 946-218 838 $145 892 $72 946-218 838 6  
 Cost of office visit $131 $66-197 $131 $66-197 21  
 Number of office visits (per mo) 10.5 5-15 10.5 5-15 6  
 Cost of hospice care (mo) $1 129 $565-1 694 $1 129 $565-1 694 11  
 Cost of supportive care (mo) $3 882 $1 941-5 823 $3 882 $1 941-5 823 10  
 Cost of terminal care $8 890 $4 445-13 335 $8 890 $4 445-13 335 6  
 Unplanned admission     6  
  Likelihood of unplanned admission 0.4/mo 0.2-0.6/mo 0.4/mo 0.2-0.6/mo  
  Costs per episode $17 220 $8 610-25 830 $17 220 $8 610-25 830  
 ED visits     6  
  Likelihood of ED visit 0.11/mo 0.06-0.17/mo 0.11/mo 0.06-0.17/mo  
  Costs per episode $1 030 $515-1 545 $1 030 $515-1 545  
Utilities      
 Utility during induction (months 0-2) 0.44 0.40-0.48 0.40 0.36-0.44 13  
 Utility during temporary remission (3-5 mo) 0.66 0.60-0.72 0.66 0.60-0.72 13  
 Utility during long-term remission (≥6 mo) 0.82 0.74-0.90 0.82 0.74-0.90 14  
 Utility during disease relapse 0.53 0.48-0.58 0.53 0.48-0.53 14  

BSC, best supportive care; ED, emergency department; LIT, lower-intensity therapy; N/A, not available.

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