| Chronic lymphocytic leukemia | Hypogammaglobulinemia Complement defects Cell-mediated immune defects (T-cells, delayed hypersensitivity) Neutrophil phagocytic/bactericidal activity defects Monocyte function/deficiencies in monocyte enzyme levels Potential mucosal immune defects
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| Multiple myeloma | Hypogammaglobulinemia Complement defects Cellular immune impairment Delayed hypersensitivity creating abnormal recall response Abnormal T cell response to mitogens Defective response to immunization Neutrophil phagocytic/bactericidal activity defects
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| Hairy cell leukemia | Quantitative and qualitative defect of monocytes Cytokine induced suppression Depressed T-cell function Immune defects related to therapeutic splenectomy
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| Hodgkin lymphoma | Abnormalities in cell-mediated immunity Qualitative and quantitative lymphocyte abnormalities Low T lymphocyte counts and impaired lymphocyte function State of cell-mediated suppression Delayed hypersensitivity response to recall Impaired proliferative responses
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| Non-Hodgkin lymphoma | Congenital and acquired states of immunosuppression (Ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable hypogammaglobulinemia, X-linked lymphoproliferative syndrome, and severe combined immunodeficiency, HIV EBV) T cells and NK cell failure Depression of regulatory T cells, suppressing T cell activity and resulting in further immune dysfunction
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