Cause of mortality by DLCOcSB > 60% or ≤60% of predicted in patients undergoing auto-HSCT conditioned with BEAM
| . | DLCOcSB > 60% of predicted . | DLCOcSB ≤ 60% of predicted . |
|---|---|---|
| Patients, n | 278 | 37 |
| Alive | 211 (76) | 18 (49) |
| Relapse | 57 (20) | 10 (27) |
| NRM | 8 (3) | 7 (19) |
| Cause of death (months after auto-HSCT) | Pneumocystis jiroveci pneumonia (5.6) | Aspergillosis (0.6) |
| Pneumonia, hypoxia by aspiration (0.7) | Sepsis by Pseudomonas aeruginosa (10.2) | |
| Pneumonic sepsis (4.0) | ST-elevated myocardial infarction (17.8) | |
| ARDS (0.5) | CNS-organic psycho-syndrome (2.1) | |
| Guillain-Barré syndrome (32) | Multiorgan dysfunction (1.3) | |
| Acute abdomen (3.7) | CNS hemorrhage (0.4) | |
| Hemophagocytic syndrome (43.8) | Second neoplasia (AML) (41.7) | |
| Second neoplasia (tongue carcinoma) (55) | ||
| Unknown cause of death, n (%) | 2 (1) | 2 (5) |
| . | DLCOcSB > 60% of predicted . | DLCOcSB ≤ 60% of predicted . |
|---|---|---|
| Patients, n | 278 | 37 |
| Alive | 211 (76) | 18 (49) |
| Relapse | 57 (20) | 10 (27) |
| NRM | 8 (3) | 7 (19) |
| Cause of death (months after auto-HSCT) | Pneumocystis jiroveci pneumonia (5.6) | Aspergillosis (0.6) |
| Pneumonia, hypoxia by aspiration (0.7) | Sepsis by Pseudomonas aeruginosa (10.2) | |
| Pneumonic sepsis (4.0) | ST-elevated myocardial infarction (17.8) | |
| ARDS (0.5) | CNS-organic psycho-syndrome (2.1) | |
| Guillain-Barré syndrome (32) | Multiorgan dysfunction (1.3) | |
| Acute abdomen (3.7) | CNS hemorrhage (0.4) | |
| Hemophagocytic syndrome (43.8) | Second neoplasia (AML) (41.7) | |
| Second neoplasia (tongue carcinoma) (55) | ||
| Unknown cause of death, n (%) | 2 (1) | 2 (5) |
Unless otherwise noted, data are n (%). DLCOcSB values were not available for 19 patients (5.4%) before auto-HSCT and prior to conditioning with BEAM.
AML, acute myeloid leukemia; ARDS, acute respiratory distress syndrome.