Cytotoxic activity of SAR442085, daratumumab and isatuximab against the indicated MM cell lines in the presence of NK92-FcγRIIIa cells
| Target cells . | Effector cells . | Compound . | Geometric mean EC50rel (pM) [95% CI]* . | Fold improvement† . |
|---|---|---|---|---|
| RPMI 8226 | NK92-FcγRIIIa158F | SAR442085 | 3.121 [0.19; 51.44] | 24 |
| Daratumumab | 73.26 [6.25; 858.3] | - | ||
| Isatuximab | 84.59 [2.11; 3398] | - | ||
| NK92-FcγRIIIa158V | SAR442085 | 8.41 [0.75; 94.54] | 14 | |
| Daratumumab | 118.8 [9.5; 1486] | - | ||
| Isatuximab | 65.74 [4.26; 1014] | |||
| MOLP8 | NK92-FcγRIIIa158F | SAR442085 | 1.28 [0.20; 8.39] | 28 |
| Daratumumab | 36.07 [10.68; 121.8] | - | ||
| Isatuximab | 30.28 [7.3; 125.6] | |||
| NK92-FcγRIIIa158V | SAR442085 | 2.82 [0.24; 33.18] | 15 | |
| Daratumumab | 42.21 [6.21; 287] | - | ||
| Isatuximab | 32.8 [4.69; 230] | |||
| KMS-12-BM | NK92-FcγRIIIa158F | SAR442085 | 1.969 [0.103; 37.75] | 22 |
| Daratumumab | 43.29 [1.29; 1448] | - | ||
| Isatuximab | 53.5 [2.77; 1034] | |||
| NK92-FcγRIIIa158V | SAR442085 | 4.65 [0.97; 22.39] | 13 | |
| Daratumumab | 58.58 [15.15; 310.5] | - | ||
| Isatuximab | 65.74 [4.26; 1014] |
| Target cells . | Effector cells . | Compound . | Geometric mean EC50rel (pM) [95% CI]* . | Fold improvement† . |
|---|---|---|---|---|
| RPMI 8226 | NK92-FcγRIIIa158F | SAR442085 | 3.121 [0.19; 51.44] | 24 |
| Daratumumab | 73.26 [6.25; 858.3] | - | ||
| Isatuximab | 84.59 [2.11; 3398] | - | ||
| NK92-FcγRIIIa158V | SAR442085 | 8.41 [0.75; 94.54] | 14 | |
| Daratumumab | 118.8 [9.5; 1486] | - | ||
| Isatuximab | 65.74 [4.26; 1014] | |||
| MOLP8 | NK92-FcγRIIIa158F | SAR442085 | 1.28 [0.20; 8.39] | 28 |
| Daratumumab | 36.07 [10.68; 121.8] | - | ||
| Isatuximab | 30.28 [7.3; 125.6] | |||
| NK92-FcγRIIIa158V | SAR442085 | 2.82 [0.24; 33.18] | 15 | |
| Daratumumab | 42.21 [6.21; 287] | - | ||
| Isatuximab | 32.8 [4.69; 230] | |||
| KMS-12-BM | NK92-FcγRIIIa158F | SAR442085 | 1.969 [0.103; 37.75] | 22 |
| Daratumumab | 43.29 [1.29; 1448] | - | ||
| Isatuximab | 53.5 [2.77; 1034] | |||
| NK92-FcγRIIIa158V | SAR442085 | 4.65 [0.97; 22.39] | 13 | |
| Daratumumab | 58.58 [15.15; 310.5] | - | ||
| Isatuximab | 65.74 [4.26; 1014] |