Clinical characteristics of AML patients with and without PTPN11 mutations
| Characteristic . | PTPN11mut . | PTPN11wt . | P* . |
|---|---|---|---|
| (n = 140) . | (n = 1585) . | ||
| Age, y | .74 | ||
| Median | 53 | 53 | |
| Range | 18-84 | 17-92 | |
| Sex, n (%) | .11 | ||
| Male | 70 (50) | 907 (57) | |
| Female | 70 (50) | 678 (43) | |
| Race, n (%) | .59 | ||
| White | 124 (89) | 1356 (87) | |
| Non-white | 15 (11) | 197 (13) | |
| Hemoglobin, g/dL | .93 | ||
| Median | 9.1 | 9.2 | |
| Range | 5.7-15.0 | 2.3-25.1 | |
| Platelet count, ×109/L | <.001 | ||
| Median | 72 | 54 | |
| Range | 10-648 | 4-989 | |
| WBC count, ×109/L | .22 | ||
| Median | 29.3 | 23.3 | |
| Range | 1.4-355.0 | 0.4-560.0 | |
| % Blood blasts | .90 | ||
| Median | 48 | 53 | |
| Range | 0-97 | 0-99 | |
| % BM blasts | .30 | ||
| Median | 63 | 67 | |
| Range | 12-99 | 0-99 | |
| Extramedullary involvement, n (%) | 45 (33) | 363 (24) | .03 |
| Characteristic . | PTPN11mut . | PTPN11wt . | P* . |
|---|---|---|---|
| (n = 140) . | (n = 1585) . | ||
| Age, y | .74 | ||
| Median | 53 | 53 | |
| Range | 18-84 | 17-92 | |
| Sex, n (%) | .11 | ||
| Male | 70 (50) | 907 (57) | |
| Female | 70 (50) | 678 (43) | |
| Race, n (%) | .59 | ||
| White | 124 (89) | 1356 (87) | |
| Non-white | 15 (11) | 197 (13) | |
| Hemoglobin, g/dL | .93 | ||
| Median | 9.1 | 9.2 | |
| Range | 5.7-15.0 | 2.3-25.1 | |
| Platelet count, ×109/L | <.001 | ||
| Median | 72 | 54 | |
| Range | 10-648 | 4-989 | |
| WBC count, ×109/L | .22 | ||
| Median | 29.3 | 23.3 | |
| Range | 1.4-355.0 | 0.4-560.0 | |
| % Blood blasts | .90 | ||
| Median | 48 | 53 | |
| Range | 0-97 | 0-99 | |
| % BM blasts | .30 | ||
| Median | 63 | 67 | |
| Range | 12-99 | 0-99 | |
| Extramedullary involvement, n (%) | 45 (33) | 363 (24) | .03 |
BM, bone marrow; WBC, white blood cell.
P values are from Fisher’s exact test for discrete variables and from the Wilcoxon rank sum test for continuous variables.