Table 1.

Affinities of WT1-TCB

pMHC affinitypMHC avidityCD3 affinity
KD = 50 nM (25°C)
ka = 7.7 ± 0.0 ×105 1/M s (37°C)
kd = 3.7 ± 0.0 ×10−2 1/s (37°C) 		0.45 nM WT1-TCB
KD = 3.7 ± 0.8 nM (25°C)
11.3 ± 0.1 nM (37°C)
ka = 1.4 ± 0.0 ×105 1/M s (37°C)
kd = 1.6 ± 0.0 ×10−3 1/s (37°C)
WT1-TCB*
KD = 3.0 ± 0.1 nM (25°C)
6.3 ± 0.2 nM (37°C)
ka = 2.1 ± 0.1 ×106 1/M s (37°C)
kd = 1.3 ± 0.0 ×10−2 1/s (37°C) 
pMHC affinitypMHC avidityCD3 affinity
KD = 50 nM (25°C)
ka = 7.7 ± 0.0 ×105 1/M s (37°C)
kd = 3.7 ± 0.0 ×10−2 1/s (37°C) 		0.45 nM WT1-TCB
KD = 3.7 ± 0.8 nM (25°C)
11.3 ± 0.1 nM (37°C)
ka = 1.4 ± 0.0 ×105 1/M s (37°C)
kd = 1.6 ± 0.0 ×10−3 1/s (37°C)
WT1-TCB*
KD = 3.0 ± 0.1 nM (25°C)
6.3 ± 0.2 nM (37°C)
ka = 2.1 ± 0.1 ×106 1/M s (37°C)
kd = 1.3 ± 0.0 ×10−2 1/s (37°C) 

KD, equilibrium dissociation constant; ka, association rate constant; kd, dissociation rate constant.

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