Patient and transplantation characteristics according to donor type (n = 164)
| Characteristic . | All . | T-replete HLA-matched graft . | T-depleted HLA-mismatched graft . | P . | |
|---|---|---|---|---|---|
| MFD . | MUD . | ||||
| No. | 164 | 37 | 80 | 47 | |
| Male sex, n (%) | 97 (59) | 16 (43) | 52 (65) | 29 (62) | NS |
| Diagnosis, n (%) | NS | ||||
| SCID | 35 (21) | 10 (27) | 14 (18) | 11 (23) | |
| Non-SCID IEI | 129 (79) | 27 (73) | 66 (83) | 36 (77) | |
| Age at diagnosis, median (range), y | |||||
| SCID | 0.2 (at birth-1.0) | 0.13 (at birth-0.7) | 0.3 (at birth-0.8) | 0.3 (at birth-1.04) | NS |
| Non-SCID IEI | 1.9 (at birth-17.1) | 2.1 (at birth-12.8) | 1.5 (at birth-14.3) | 2.0 (0.1-17.1) | NS |
| Age at transplant, median (range), y | |||||
| SCID | 0.4 (0.14-1.4) | 0.3 (0.2-0.8) | 0.54 (0.14-1.4) | 0.65 (0.14-1.4) | NS |
| Non-SCID IEI | 4.1 (0.2-18.1) | 4.32 (0.2-16.8) | 4.7 (0.3-17.2) | 3.1 (0.2-18.1) | NS |
| Interval between diagnosis and transplant, median (range), y | |||||
| SCID | 0.2 (0.02-1.2) | 0.16 (0.11-0.32) | 0.24 (0.02-1.2) | 0.22 (0.13-0.8) | NS |
| Non-SCID IEI | 1.2 (0.1-17.2) | 0.8 (0.2-12.8) | 1.3 (0.1-17.2) | 1.2 (0.1-4.6) | NS |
| No. of pretransplant risk factors, median (range) | |||||
| SCID | 2 (0-4) | 1 (0-3) | 2 (0-4) | 2 (0-3) | NS |
| Non-SCID IEI | 2 (0-6) | 1 (0-5) | 2 (0-6) | 2 (0-5) | NS |
| Graft composition | |||||
| Median TNC (range), ×108/kg | 12.0 (1.0-96.0) | 7.6 (1.4-22.8) | 13.9 (1.2 – 37.9) | 10 (1.0-96.0) | <.0001 |
| Median CD34+ (range), ×106/kg | 12.4 (0.5-60.9) | 6.7 (1.7-25.7) | 13.5 (0.5-8.7) | 18.4 (0.8-60.9) | <.0001 |
| CD3+ (range), ×108/kg | 1.9 (0.02-14.4) | 0.9 (0.2-7.7) | 4.6 (0.3-8.7) | 0.2 (0.02-14.4)* | <.0001 |
| CD19+ (range), ×107/kg | 5.25 (0.0008-27.0) | 5.0 (1.1-21.0) | 9.4 (0.7-27.0) | 0.007 (0.008-0.11) | <.0001 |
| Characteristic . | All . | T-replete HLA-matched graft . | T-depleted HLA-mismatched graft . | P . | |
|---|---|---|---|---|---|
| MFD . | MUD . | ||||
| No. | 164 | 37 | 80 | 47 | |
| Male sex, n (%) | 97 (59) | 16 (43) | 52 (65) | 29 (62) | NS |
| Diagnosis, n (%) | NS | ||||
| SCID | 35 (21) | 10 (27) | 14 (18) | 11 (23) | |
| Non-SCID IEI | 129 (79) | 27 (73) | 66 (83) | 36 (77) | |
| Age at diagnosis, median (range), y | |||||
| SCID | 0.2 (at birth-1.0) | 0.13 (at birth-0.7) | 0.3 (at birth-0.8) | 0.3 (at birth-1.04) | NS |
| Non-SCID IEI | 1.9 (at birth-17.1) | 2.1 (at birth-12.8) | 1.5 (at birth-14.3) | 2.0 (0.1-17.1) | NS |
| Age at transplant, median (range), y | |||||
| SCID | 0.4 (0.14-1.4) | 0.3 (0.2-0.8) | 0.54 (0.14-1.4) | 0.65 (0.14-1.4) | NS |
| Non-SCID IEI | 4.1 (0.2-18.1) | 4.32 (0.2-16.8) | 4.7 (0.3-17.2) | 3.1 (0.2-18.1) | NS |
| Interval between diagnosis and transplant, median (range), y | |||||
| SCID | 0.2 (0.02-1.2) | 0.16 (0.11-0.32) | 0.24 (0.02-1.2) | 0.22 (0.13-0.8) | NS |
| Non-SCID IEI | 1.2 (0.1-17.2) | 0.8 (0.2-12.8) | 1.3 (0.1-17.2) | 1.2 (0.1-4.6) | NS |
| No. of pretransplant risk factors, median (range) | |||||
| SCID | 2 (0-4) | 1 (0-3) | 2 (0-4) | 2 (0-3) | NS |
| Non-SCID IEI | 2 (0-6) | 1 (0-5) | 2 (0-6) | 2 (0-5) | NS |
| Graft composition | |||||
| Median TNC (range), ×108/kg | 12.0 (1.0-96.0) | 7.6 (1.4-22.8) | 13.9 (1.2 – 37.9) | 10 (1.0-96.0) | <.0001 |
| Median CD34+ (range), ×106/kg | 12.4 (0.5-60.9) | 6.7 (1.7-25.7) | 13.5 (0.5-8.7) | 18.4 (0.8-60.9) | <.0001 |
| CD3+ (range), ×108/kg | 1.9 (0.02-14.4) | 0.9 (0.2-7.7) | 4.6 (0.3-8.7) | 0.2 (0.02-14.4)* | <.0001 |
| CD19+ (range), ×107/kg | 5.25 (0.0008-27.0) | 5.0 (1.1-21.0) | 9.4 (0.7-27.0) | 0.007 (0.008-0.11) | <.0001 |
NS, not significant; TNC, total nucleated cell.
Median TCRαβ+ cell dose, 4.1 × 104/kg (range, 0.06-20 × 104/kg).