Measurements of whole blood platelet count, MPV, PR, aPTT, fibrinogen concentration, and VWF activity and antigen
| . | Mean ± SEM . | Healthy controls, range . | |
|---|---|---|---|
| NS patients (n = 10) . | NSML patients (n = 3) . | ||
| Platelet count, ×109/L* | 231 ± 32 | 282 ± 44 | 150-450 |
| MPV, fL* | 10.2 ± 0.3 | 10.5 ± 1.0 | 8.5-12 |
| PR, %† | 81.3 ± 2.7 | 92.3 ± 3.9 | 70-100 |
| aPTT ratio† | 1.3 ± 0.1 | 1.1 ± 0.1 | <1.2 |
| Fibrinogen, g/L† | 2.8 ± 0.2 | 3.0 ± 0.5 | 2.0-4.0 |
| VWF activity, %† | 76.5 ± 6.8 | 73.3 ± 16.9 | 50-160 |
| VWF antigen, %† | 86.2 ± 9.6 | 84.3 ± 13.7 | 50-120 |
| . | Mean ± SEM . | Healthy controls, range . | |
|---|---|---|---|
| NS patients (n = 10) . | NSML patients (n = 3) . | ||
| Platelet count, ×109/L* | 231 ± 32 | 282 ± 44 | 150-450 |
| MPV, fL* | 10.2 ± 0.3 | 10.5 ± 1.0 | 8.5-12 |
| PR, %† | 81.3 ± 2.7 | 92.3 ± 3.9 | 70-100 |
| aPTT ratio† | 1.3 ± 0.1 | 1.1 ± 0.1 | <1.2 |
| Fibrinogen, g/L† | 2.8 ± 0.2 | 3.0 ± 0.5 | 2.0-4.0 |
| VWF activity, %† | 76.5 ± 6.8 | 73.3 ± 16.9 | 50-160 |
| VWF antigen, %† | 86.2 ± 9.6 | 84.3 ± 13.7 | 50-120 |
Data shown for 10 NS patients and 3 NSML patients, with range of raw values for healthy controls.
MPV, mean platelet volume.
Whole-blood platelet count and MPV were measured by using a HORIBA ABX Micros 60 analyzer (n = 22 mice of each genotype).
PR, aPTT ratio, fibrinogen concentration and VWF parameters were measured as described in “Methods.”