Enrichment analysis of biomarkers inTable 3
| Source . | Term . | Overlap . | Genes . | Q . |
|---|---|---|---|---|
| KEGG_2019_Human | Cytokine-cytokine receptor interaction | 7/294 | CCL13;GH1;CSF3;CXCL11;CXCL12;IL1R1;CCL18 | 7.9e-08 |
| GeneSigDB | 20460173-ImmPortCytokines | 8/444 | CCL13;GH1;CSF3;CXCL11;CXCL12;CCL18;TSHB;HBEGF | 1.89e-07 |
| GO_Molecular_Function_2018 | Chemokine activity (GO:0008009) | 4/46 | CCL13;CXCL11;CXCL12;CCL18 | 1.16e-06 |
| GO_Molecular_Function_2018 | Chemokine receptor binding (GO:0042379) | 4/49 | CCL13;CXCL11;CXCL12;CCL18 | 1.16e-06 |
| GO_Molecular_Function_2018 | Cytokine activity (GO:0005125) | 5/155 | CCL13;CSF3;CXCL11;CXCL12;CCL18 | 1.46e-06 |
| GO_Biological_Process_2018 | Chemokine-mediated signaling pathway (GO:0070098) | 4/52 | CCL13;CXCL11;CXCL12;CCL18 | 2.17e-05 |
| GO_Biological_Process_2018 | Cytokine-mediated signaling pathway (GO:0019221) | 7/633 | CCL13;CSF3;CXCL11;CXCL12;IL1R1;CCL18;SOD1 | 4.12e-05 |
| Elsevier_Pathway_Collection | Proteins involved in atherosclerosis | 5/200 | GH1;CSF3;CXCL11;CXCL12;HBEGF | 0.000103 |
| GeneSigDB | 20460173-ImmPortChemokines | 4/97 | CCL13;CXCL11;CXCL12;CCL18 | 0.00014 |
| Elsevier_Pathway_Collection | Proteins involved in myocardial ischemia | 5/252 | GH1;CSF3;CXCL12;MB;SOD1 | 0.000161 |
| EnrichR_Users_Contributed_Lists_2020 | Secretome from protein atlas | 11/2640 | CCL13;GH1;CSF3;CXCL11;CXCL12;IL1R1;CGB3; FOLR3;CCL18;TSHB;HBEGF | 0.000206 |
| GO_Molecular_Function_2018 | Growth factor activity (GO:0008083) | 3/69 | GH1;CSF3;HBEGF | 0.000218 |
| GO_Molecular_Function_2018 | Hormone activity (GO:0005179) | 3/83 | GH1;CGB3;TSHB | 0.000304 |
| GO_Molecular_Function_2018 | Growth factor receptor binding (GO:0070851) | 3/92 | CSF3;IL1R1;HBEGF | 0.000345 |
| MSigDB_Hallmark_2020 | Inflammatory response | 4/200 | CSF3;CXCL11;IL1R1;HBEGF | 0.000354 |
| KEGG_2019_Human | Chemokine signaling pathway | 4/190 | CCL13;CXCL11;CXCL12;CCL18 | 0.000368 |
| GO_Molecular_Function_2018 | CXCR chemokine receptor binding (GO:0045236) | 2/17 | CXCL11;CXCL12 | 0.000475 |
| GO_Biological_Process_2018 | Lymphocyte chemotaxis (GO:0048247) | 3/44 | CCL13;CXCL11;CCL18 | 0.000545 |
| GO_Molecular_Function_2018 | Cytokine receptor binding (GO:0005126) | 3/137 | GH1;CSF3;CXCL12 | 0.000845 |
| Elsevier_Pathway_Collection | Proteins involved in diabetic nephropathy | 4/175 | GH1;CXCL12;SOD1;HBEGF | 0.000855 |
| Source . | Term . | Overlap . | Genes . | Q . |
|---|---|---|---|---|
| KEGG_2019_Human | Cytokine-cytokine receptor interaction | 7/294 | CCL13;GH1;CSF3;CXCL11;CXCL12;IL1R1;CCL18 | 7.9e-08 |
| GeneSigDB | 20460173-ImmPortCytokines | 8/444 | CCL13;GH1;CSF3;CXCL11;CXCL12;CCL18;TSHB;HBEGF | 1.89e-07 |
| GO_Molecular_Function_2018 | Chemokine activity (GO:0008009) | 4/46 | CCL13;CXCL11;CXCL12;CCL18 | 1.16e-06 |
| GO_Molecular_Function_2018 | Chemokine receptor binding (GO:0042379) | 4/49 | CCL13;CXCL11;CXCL12;CCL18 | 1.16e-06 |
| GO_Molecular_Function_2018 | Cytokine activity (GO:0005125) | 5/155 | CCL13;CSF3;CXCL11;CXCL12;CCL18 | 1.46e-06 |
| GO_Biological_Process_2018 | Chemokine-mediated signaling pathway (GO:0070098) | 4/52 | CCL13;CXCL11;CXCL12;CCL18 | 2.17e-05 |
| GO_Biological_Process_2018 | Cytokine-mediated signaling pathway (GO:0019221) | 7/633 | CCL13;CSF3;CXCL11;CXCL12;IL1R1;CCL18;SOD1 | 4.12e-05 |
| Elsevier_Pathway_Collection | Proteins involved in atherosclerosis | 5/200 | GH1;CSF3;CXCL11;CXCL12;HBEGF | 0.000103 |
| GeneSigDB | 20460173-ImmPortChemokines | 4/97 | CCL13;CXCL11;CXCL12;CCL18 | 0.00014 |
| Elsevier_Pathway_Collection | Proteins involved in myocardial ischemia | 5/252 | GH1;CSF3;CXCL12;MB;SOD1 | 0.000161 |
| EnrichR_Users_Contributed_Lists_2020 | Secretome from protein atlas | 11/2640 | CCL13;GH1;CSF3;CXCL11;CXCL12;IL1R1;CGB3; FOLR3;CCL18;TSHB;HBEGF | 0.000206 |
| GO_Molecular_Function_2018 | Growth factor activity (GO:0008083) | 3/69 | GH1;CSF3;HBEGF | 0.000218 |
| GO_Molecular_Function_2018 | Hormone activity (GO:0005179) | 3/83 | GH1;CGB3;TSHB | 0.000304 |
| GO_Molecular_Function_2018 | Growth factor receptor binding (GO:0070851) | 3/92 | CSF3;IL1R1;HBEGF | 0.000345 |
| MSigDB_Hallmark_2020 | Inflammatory response | 4/200 | CSF3;CXCL11;IL1R1;HBEGF | 0.000354 |
| KEGG_2019_Human | Chemokine signaling pathway | 4/190 | CCL13;CXCL11;CXCL12;CCL18 | 0.000368 |
| GO_Molecular_Function_2018 | CXCR chemokine receptor binding (GO:0045236) | 2/17 | CXCL11;CXCL12 | 0.000475 |
| GO_Biological_Process_2018 | Lymphocyte chemotaxis (GO:0048247) | 3/44 | CCL13;CXCL11;CCL18 | 0.000545 |
| GO_Molecular_Function_2018 | Cytokine receptor binding (GO:0005126) | 3/137 | GH1;CSF3;CXCL12 | 0.000845 |
| Elsevier_Pathway_Collection | Proteins involved in diabetic nephropathy | 4/175 | GH1;CXCL12;SOD1;HBEGF | 0.000855 |
Source, pathway/gene set source; Term, pathway/gene set; overlap, number of genes in Table 3/number of genes in pathway; Genes, genes in Table 3 in pathway; Q, enrichment Q-value.