Clinical and hematological features of individuals included in the study
| Variable . | Healthy subjects . | Anemia of the elderly . | Cytopenia of undetermined significance . | Myeloid neoplasm with myelodysplasia . |
|---|---|---|---|---|
| Patients, n | 355 | 177 | 311 | 592 |
| Sex, male/female | 154/201 | 87/90 | 144/167 | 365/227 |
| Age, y, median (range) | 70 (60-94) | 72 (60-102) | 58 (19-89) | 67 (18-93) |
| Hb, g/dL, median (range) | 14.4 (12.1-18.4) | 12.0 (6.8-17.6) | 12.7 (5.9-16.4) | 10.2 (3.33-17.4) |
| MCV, fL, median (range) | 90.6 (74.0-99.6) | 94.0 (60.3-114.3) | 91.9 (61.7-121.0) | 98.0 (56.1-134.6) |
| WBC, ×109/L, median (range) | 5.94 (2.79-12.44) | 6.07 (3.53-12.9) | 3.48 (0.87-16.0) | 4.66 (0.7-164.0) |
| ANC, ×109/L, median (range) | 3.36 (1.42-7.88) | 3.66 (1.54-6.3) | 1.63 (0.05-10.9) | 2.16 (0.04-109.62) |
| PLT, ×109/L, median (range) | 224 (101-421) | 230.5 (113-481) | 152 (10-917) | 148 (6-1383) |
| BM blasts, %, median (range) | — | — | 2 (1-3) | 2 (1-98) |
| WHO category | ||||
| MDS | — | — | — | 405 |
| MDS/MPN | — | — | — | 152 |
| AML-MRC | — | — | — | 35 |
| Variable . | Healthy subjects . | Anemia of the elderly . | Cytopenia of undetermined significance . | Myeloid neoplasm with myelodysplasia . |
|---|---|---|---|---|
| Patients, n | 355 | 177 | 311 | 592 |
| Sex, male/female | 154/201 | 87/90 | 144/167 | 365/227 |
| Age, y, median (range) | 70 (60-94) | 72 (60-102) | 58 (19-89) | 67 (18-93) |
| Hb, g/dL, median (range) | 14.4 (12.1-18.4) | 12.0 (6.8-17.6) | 12.7 (5.9-16.4) | 10.2 (3.33-17.4) |
| MCV, fL, median (range) | 90.6 (74.0-99.6) | 94.0 (60.3-114.3) | 91.9 (61.7-121.0) | 98.0 (56.1-134.6) |
| WBC, ×109/L, median (range) | 5.94 (2.79-12.44) | 6.07 (3.53-12.9) | 3.48 (0.87-16.0) | 4.66 (0.7-164.0) |
| ANC, ×109/L, median (range) | 3.36 (1.42-7.88) | 3.66 (1.54-6.3) | 1.63 (0.05-10.9) | 2.16 (0.04-109.62) |
| PLT, ×109/L, median (range) | 224 (101-421) | 230.5 (113-481) | 152 (10-917) | 148 (6-1383) |
| BM blasts, %, median (range) | — | — | 2 (1-3) | 2 (1-98) |
| WHO category | ||||
| MDS | — | — | — | 405 |
| MDS/MPN | — | — | — | 152 |
| AML-MRC | — | — | — | 35 |
ANC, absolute neutrophil count; BM, bone marrow; Hb, hemoglobin; MCV, mean corpuscular volume; PLT, platelet; WBC, white blood cell; WHO, World Health Organization.