Summary of AEs occurring in at least 10% of patients
. | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Total . |
---|---|---|---|---|---|
All AEs of any grade | 30 (100) | 16 (53) | 4 (13) | 1 (3) | 30 (100) |
Immune related | |||||
Any AE | 24 (80) | 12 (40) | 3 (10) | 1 (3) | 24 (80) |
AST increased | 8 (27) | 0 | 0 | 1 (3) | 9 (30) |
ALT increased | 2 (7) | 0 | 0 | 1 (3) | 3 (10) |
Diarrhea | 7 (23) | 5 (17) | 1 (3) | 0 | 13 (43) |
Rash | 4 (13) | 3 (10) | 0 | 0 | 7 (23) |
Thyroid dysfunction | 9 (30) | 0 | 0 | 0 | 9 (30) |
Pneumonitis | 0 | 3 (10) | 0 | 0 | 3 (10) |
Aseptic meningitis | 0 | 0 | 1 (3) | 0 | 1 (3) |
Pancreatitis | 1 (3) | 0 | 1 (3) | 0 | 2 (7) |
Gastritis/esophagitis | 1 (3) | 1 (3) | 0 | 0 | 2 (7) |
Mucositis (oral) | 9 (30) | 1 (3) | 0 | 0 | 10 (33) |
Episcleritis | 1 (3) | 0 | 0 | 0 | 1 (3) |
Nonimmune related | |||||
Any AE | 30 (100) | 4 (13) | 1 (3) | 0 | 30 (100) |
Nausea / vomiting | 8 (27) | 2 (7) | 1 (3) | 0 | 11 (37) |
Ocular symptoms | 10 (33) | 2 (7) | 0 | 0 | 12 (40) |
Myalgia | 8 (27) | 0 | 0 | 0 | 8 (27) |
Dyspnea/wheezing | 4 (13) | 0 | 0 | 0 | 4 (13) |
Leukopenia | 4 (13) | 0 | 0 | 0 | 4 (13) |
. | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Total . |
---|---|---|---|---|---|
All AEs of any grade | 30 (100) | 16 (53) | 4 (13) | 1 (3) | 30 (100) |
Immune related | |||||
Any AE | 24 (80) | 12 (40) | 3 (10) | 1 (3) | 24 (80) |
AST increased | 8 (27) | 0 | 0 | 1 (3) | 9 (30) |
ALT increased | 2 (7) | 0 | 0 | 1 (3) | 3 (10) |
Diarrhea | 7 (23) | 5 (17) | 1 (3) | 0 | 13 (43) |
Rash | 4 (13) | 3 (10) | 0 | 0 | 7 (23) |
Thyroid dysfunction | 9 (30) | 0 | 0 | 0 | 9 (30) |
Pneumonitis | 0 | 3 (10) | 0 | 0 | 3 (10) |
Aseptic meningitis | 0 | 0 | 1 (3) | 0 | 1 (3) |
Pancreatitis | 1 (3) | 0 | 1 (3) | 0 | 2 (7) |
Gastritis/esophagitis | 1 (3) | 1 (3) | 0 | 0 | 2 (7) |
Mucositis (oral) | 9 (30) | 1 (3) | 0 | 0 | 10 (33) |
Episcleritis | 1 (3) | 0 | 0 | 0 | 1 (3) |
Nonimmune related | |||||
Any AE | 30 (100) | 4 (13) | 1 (3) | 0 | 30 (100) |
Nausea / vomiting | 8 (27) | 2 (7) | 1 (3) | 0 | 11 (37) |
Ocular symptoms | 10 (33) | 2 (7) | 0 | 0 | 12 (40) |
Myalgia | 8 (27) | 0 | 0 | 0 | 8 (27) |
Dyspnea/wheezing | 4 (13) | 0 | 0 | 0 | 4 (13) |
Leukopenia | 4 (13) | 0 | 0 | 0 | 4 (13) |
Data are expressed as the number (percentage of each group).
ALT, alanine transaminase; AST, aspartate aminotransferase; Gd, grade.