Recommended diagnostic evaluation
| Baseline information . | Tests required . |
|---|---|
| Histological diagnosis via excisional biopsy preferred | • According to WHO criteria, including COO phenotype (gene expression profiling or IHC) and FISH for MYC, BCL2, and BCL6 |
| Clinical assessment | • Age • Performance status • B symptoms • Comorbidities |
| Staging Including documentation of: Ann Arbor stage Extranodal sites Presence of bulk | • PET-CT • Other radiological tests as indicated • Bone marrow biopsy (optional but preferred) |
| Organ function | • Laboratory tests: ○ Lactate dehydrogenase (LDH) ○ Complete blood count ○ Urea, creatinine and electrolytes ○ Liver function tests ○ Hepatitis B and C serology ○ HIV serology • Left ventricular ejection fraction: transthoracic echocardiogram or gated cardiac blood pool scan |
| Baseline information . | Tests required . |
|---|---|
| Histological diagnosis via excisional biopsy preferred | • According to WHO criteria, including COO phenotype (gene expression profiling or IHC) and FISH for MYC, BCL2, and BCL6 |
| Clinical assessment | • Age • Performance status • B symptoms • Comorbidities |
| Staging Including documentation of: Ann Arbor stage Extranodal sites Presence of bulk | • PET-CT • Other radiological tests as indicated • Bone marrow biopsy (optional but preferred) |
| Organ function | • Laboratory tests: ○ Lactate dehydrogenase (LDH) ○ Complete blood count ○ Urea, creatinine and electrolytes ○ Liver function tests ○ Hepatitis B and C serology ○ HIV serology • Left ventricular ejection fraction: transthoracic echocardiogram or gated cardiac blood pool scan |
FISH, fluorescence in situ hybridization; PET-CT, positron-emission tomography with computed tomography.