Table 1. Results from kinase assay... | American Society of Hematology

Table 1.

Results from kinase assay showing activity of vecabrutinib against TEC family and other kinases

Kinases	IC₅₀ (nM)
TEC family
BTK	3
ITK	14
TEC (activated)	14
TXK	474
BMX	224
Other
LCK (activated)	8
cSRC	84
BLK	23
NEK11	90
EGFR	>6000

Kinases	IC₅₀ (nM)
TEC family
BTK	3
ITK	14
TEC (activated)	14
TXK	474
BMX	224
Other
LCK (activated)	8
cSRC	84
BLK	23
NEK11	90
EGFR	>6000