Prevalence comparisons of FVIII-binding Ig isotypes and IgG subclass antibodies with confirmed FVIII specificity
| IgG subclass/Ig isotype . | Cohort comparison (patients with FVIII-specific Igs) . | Statistical test . | P value . |
|---|---|---|---|
| Pooled Igs | healthy (11) vs nsHA (33) | X | .000*** |
| healthy (11) vs sHA (10) | X | .058 | |
| nsHA (33) vs sHA (10) | X | .106 | |
| IgG1 | healthy (5) vs nsHA (26) | X | .000*** |
| healthy (5) vs sHA (7) | FET | .043* | |
| nsHA (26) vs sHA (7) | X | .104 | |
| IgA | healthy (5) vs nsHA (17) | X | .003** |
| healthy (5) vs sHA (4) | FET | .452 | |
| nsHA (17) vs sHA (4) | X2 | .147 |
| IgG subclass/Ig isotype . | Cohort comparison (patients with FVIII-specific Igs) . | Statistical test . | P value . |
|---|---|---|---|
| Pooled Igs | healthy (11) vs nsHA (33) | X | .000*** |
| healthy (11) vs sHA (10) | X | .058 | |
| nsHA (33) vs sHA (10) | X | .106 | |
| IgG1 | healthy (5) vs nsHA (26) | X | .000*** |
| healthy (5) vs sHA (7) | FET | .043* | |
| nsHA (26) vs sHA (7) | X | .104 | |
| IgA | healthy (5) vs nsHA (17) | X | .003** |
| healthy (5) vs sHA (4) | FET | .452 | |
| nsHA (17) vs sHA (4) | X2 | .147 |
See Table 1 for definitions; X2, χ-squared test; FET, Fisher’s exact test; P value, level of significance (P ≤ .050).
Significant P values are indicated in bold and marked with asterisk(s): *P ≤ .050; **P ≤ .010; ***P ≤ .001.