Univariate and multivariate logistic regression analyses for major and deep response in 319 patients with WM treated with ibrutinib monotherapy
| Major response . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|
| Variables . | OR (95% CI) . | P . | OR (95% CI) . | P . |
| Age >65 years | 1.53 (0.90-2.61) | .12 | ||
| Male sex | 1.19 (0.69-2.06) | .53 | ||
| Hemoglobin <11.5 g/dl | 2.25 (1.28-3.93) | .005 | 2.72 (1.25-5.95) | .01 |
| Platelet <100 k/ul | 0.50 (0.25-2.45) | .05 | ||
| β2-microglobulin >3 mg/l | 2.41 (1.31-4.43) | .005 | 1.54 (0.68-3.45) | .30 |
| Albumin <3.5 g/dl | 1.69 (0.88-3.24) | .12 | ||
| Serum IgM >4000 mg/dl | 1.29 (0.74-2.24) | .36 | ||
| Serum IgM >7000 mg/dl | 0.40 (0.14-1.17) | .09 | ||
| Bone marrow >60% | 2.03 (1.14-3.62) | .02 | 2.26 (0.98-5.21) | .06 |
| Previously treated | 0.92 (0.52-1.64) | .78 | ||
| CXCR4 mutated | 0.33 (0.17-0.61) | <.001 | 0.20 (0.09-0.45) | <.001 |
| CXCR4 WT | 1.00 | 1.00 | ||
| CXCR4 NS | 0.24 (0.12-0.48) | <.001 | 0.19 (0.01-0.37) | <.001 |
| CXCR4 FS | 0.69 (0.25-1.87) | .47 | 0.40 (0.13-1.23) | .11 |
| Deep response | Univariate analysis | Multivariate analysis | ||
| Variables | OR (95% CI) | P | OR (95% CI) | P |
| Age >65 years | 1.04 (0.63-1.71) | .88 | ||
| Male sex | 1.08 (0.65-1.82) | .76 | ||
| Hemoglobin <11.5 g/dl | 1.94 (1.07-3.53) | .03 | 2.34 (1.14-4.80) | .02 |
| Platelet <100 k/ul | 1.03 (0.50-2.11) | .94 | ||
| β2-microglobulin >3 mg/l | 1.46 (0.81-2.64) | .21 | ||
| Albumin <3.5 g/dl | 1.70 (1.01-2.88) | .05 | ||
| Serum IgM >4000 mg/dl | 0.60 (0.36-1.01) | .05 | ||
| Serum IgM >7000 mg/dl | 0.64 (0.18-2.34) | .50 | ||
| Bone marrow >60% | 1.65 (0.96-2.83) | .07 | ||
| Previously treated | 1.31 (0.76-2.25) | .33 | ||
| CXCR4 mutated | 0.34 (0.18-0.66) | .001 | 0.32 (0.15-0.55) | .001 |
| CXCR4 WT | 1.00 | 1.00 | ||
| CXCR4 NS | 0.26 (0.11-0.61) | .002 | 0.25 (0.11-0.60) | .002 |
| CXCR4 FS | 0.53 (0.21-1.31) | .17 | 0.47 (0.19-1.16) | .11 |
| Major response . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|
| Variables . | OR (95% CI) . | P . | OR (95% CI) . | P . |
| Age >65 years | 1.53 (0.90-2.61) | .12 | ||
| Male sex | 1.19 (0.69-2.06) | .53 | ||
| Hemoglobin <11.5 g/dl | 2.25 (1.28-3.93) | .005 | 2.72 (1.25-5.95) | .01 |
| Platelet <100 k/ul | 0.50 (0.25-2.45) | .05 | ||
| β2-microglobulin >3 mg/l | 2.41 (1.31-4.43) | .005 | 1.54 (0.68-3.45) | .30 |
| Albumin <3.5 g/dl | 1.69 (0.88-3.24) | .12 | ||
| Serum IgM >4000 mg/dl | 1.29 (0.74-2.24) | .36 | ||
| Serum IgM >7000 mg/dl | 0.40 (0.14-1.17) | .09 | ||
| Bone marrow >60% | 2.03 (1.14-3.62) | .02 | 2.26 (0.98-5.21) | .06 |
| Previously treated | 0.92 (0.52-1.64) | .78 | ||
| CXCR4 mutated | 0.33 (0.17-0.61) | <.001 | 0.20 (0.09-0.45) | <.001 |
| CXCR4 WT | 1.00 | 1.00 | ||
| CXCR4 NS | 0.24 (0.12-0.48) | <.001 | 0.19 (0.01-0.37) | <.001 |
| CXCR4 FS | 0.69 (0.25-1.87) | .47 | 0.40 (0.13-1.23) | .11 |
| Deep response | Univariate analysis | Multivariate analysis | ||
| Variables | OR (95% CI) | P | OR (95% CI) | P |
| Age >65 years | 1.04 (0.63-1.71) | .88 | ||
| Male sex | 1.08 (0.65-1.82) | .76 | ||
| Hemoglobin <11.5 g/dl | 1.94 (1.07-3.53) | .03 | 2.34 (1.14-4.80) | .02 |
| Platelet <100 k/ul | 1.03 (0.50-2.11) | .94 | ||
| β2-microglobulin >3 mg/l | 1.46 (0.81-2.64) | .21 | ||
| Albumin <3.5 g/dl | 1.70 (1.01-2.88) | .05 | ||
| Serum IgM >4000 mg/dl | 0.60 (0.36-1.01) | .05 | ||
| Serum IgM >7000 mg/dl | 0.64 (0.18-2.34) | .50 | ||
| Bone marrow >60% | 1.65 (0.96-2.83) | .07 | ||
| Previously treated | 1.31 (0.76-2.25) | .33 | ||
| CXCR4 mutated | 0.34 (0.18-0.66) | .001 | 0.32 (0.15-0.55) | .001 |
| CXCR4 WT | 1.00 | 1.00 | ||
| CXCR4 NS | 0.26 (0.11-0.61) | .002 | 0.25 (0.11-0.60) | .002 |
| CXCR4 FS | 0.53 (0.21-1.31) | .17 | 0.47 (0.19-1.16) | .11 |
MYD88 mutational status was not included as sample size for MYD88 wild-type status was small (n = 8).
FS, frameshift; NS, nonsense; WT, wild type.