Dose-response equations
| Late toxicity . | Excess relative risk per Gy equation . | Input dosimetry variable . | Relative risk . |
|---|---|---|---|
| Breast cancer4 | No excess risk for first 5 y after treatment. Thereafter, age at treatment: <19 y, ERR/Gy = 0.257; 20-24 y, ERR/Gy = 0.097; 25-29 y, ERR/Gy = 0.057; 30-34 y, ERR/Gy = 0.043; >34 y, ERR/Gy = 0.030 | MBD | RR = 1 + (ERR/Gy × MBD × 1·608*) |
| Lung cancer5,6 | No excess risk for first 5 y after treatment. Thereafter: ERR/Gy, 0.15 (95% CI: 0.06-0.39) | MLD | RR=1+(ERR/Gy × MLD × 1·672*) |
| CHD7 | No excess risk for first 5 y after treatment. Thereafter, age at treatment: <28 y, ERR/Gy = 0.200 (95% CI: 0.052-0.070); 28-36 y, ERR/Gy = 0.088 (95% CI: 0.026-0.229); >36 y, ERR/Gy = 0.042 (95% CI: 0.006-0.111) | MHD | RR = 1 + ERR × MHD |
| Ischemic stroke8 | No excess risk for first 5 y after treatment. Thereafter, age at treatment: <21 y, ERR/Gy = 0.068 (95% CI: 0.015-0.156); 21-30 y, ERR/Gy = 0.051 (95% CI: 0.022-0.088); 31-40 y, ERR/Gy = 0.024 (95% CI: 0.005-0.051); >40 y, ERR/Gy = 0.0098 (95% CI: −0.007-0.032) | MDCCA | RR = 1 + ERR × MDCCA |
| Late toxicity . | Excess relative risk per Gy equation . | Input dosimetry variable . | Relative risk . |
|---|---|---|---|
| Breast cancer4 | No excess risk for first 5 y after treatment. Thereafter, age at treatment: <19 y, ERR/Gy = 0.257; 20-24 y, ERR/Gy = 0.097; 25-29 y, ERR/Gy = 0.057; 30-34 y, ERR/Gy = 0.043; >34 y, ERR/Gy = 0.030 | MBD | RR = 1 + (ERR/Gy × MBD × 1·608*) |
| Lung cancer5,6 | No excess risk for first 5 y after treatment. Thereafter: ERR/Gy, 0.15 (95% CI: 0.06-0.39) | MLD | RR=1+(ERR/Gy × MLD × 1·672*) |
| CHD7 | No excess risk for first 5 y after treatment. Thereafter, age at treatment: <28 y, ERR/Gy = 0.200 (95% CI: 0.052-0.070); 28-36 y, ERR/Gy = 0.088 (95% CI: 0.026-0.229); >36 y, ERR/Gy = 0.042 (95% CI: 0.006-0.111) | MHD | RR = 1 + ERR × MHD |
| Ischemic stroke8 | No excess risk for first 5 y after treatment. Thereafter, age at treatment: <21 y, ERR/Gy = 0.068 (95% CI: 0.015-0.156); 21-30 y, ERR/Gy = 0.051 (95% CI: 0.022-0.088); 31-40 y, ERR/Gy = 0.024 (95% CI: 0.005-0.051); >40 y, ERR/Gy = 0.0098 (95% CI: −0.007-0.032) | MDCCA | RR = 1 + ERR × MDCCA |
ERR/Gy, excess relative risk per Gray; MBD, mean breast dose to bilateral breast tissue; MDCCA, mean dose to the common carotid arteries; MHD, mean heart dose to the whole heart; MLD, mean lung dose to the whole lungs; RR, relative risk.
Adjustment factors to allow the use of mean organ dose for predictions (rather than point dose at site of second cancer development) with derivation provided in supplemental Material.