Univariate analysis comparing the cytokine profiles of 19 Cdkn2a−/−Il10+/+ controls and 18 Cdkn2a−/−Il10−/− mice
| Cytokine . | Cdkn2a−/−Il10+/+ mice (pg/mL)* . | Cdkn2a−/−Il10−/− mice (pg/mL)* . | Nominal P . | Corrected P . | Fold change (relative to control) . |
|---|---|---|---|---|---|
| IL-6 | 6.49 | 98.12 | 1.098E-06 | 3.513E-05 | 15.12 |
| RANTES | 134.06 | 324.87 | 2.226E-06 | 7.123E-05 | 2.42 |
| G-CSF | 210.69 | 3762.93 | 3.526E-06 | .0001 | 17.86 |
| MCP-1 | 197.09 | 570.07 | 4.716E-06 | .0002 | 2.89 |
| IL-17A | 11.68 | 106.88 | 8.679E-06 | .0003 | 9.15 |
| IL-12p40 | 1155.44 | 3178.86 | 1.701E-05 | .0005 | 2.75 |
| MIP-1β | 17.70 | 54.20 | 4.850E-05 | .0016 | 3.06 |
| IFN-γ | 9.20 | 53.65 | 6.343E-05 | .0020 | 5.83 |
| IL-3 | 1.64 | 6.57 | 6.831E-05 | .0022 | 4.00 |
| IL-1β | 2.02 | 5.43 | .0001 | .0034 | 2.69 |
| GM-CSF | 72.45 | 179.37 | .0003 | .0111 | 2.48 |
| IL-5 | 2.08 | 24.29 | .0004 | .0113 | 11.68 |
| TNF-α | 18.62 | 70.41 | .0006 | .0201 | 3.78 |
| MIP-1α | 3.96 | 8.80 | .0008 | .0261 | 2.22 |
| IL-1α | 19.88 | 45.34 | .0012 | .0389 | 2.28 |
| IL-9 | 3.66 | 23.98 | .0022 | .0705 | 6.55 |
| IL-12p70 | 39.63 | 83.49 | .0037 | .1193 | 2.11 |
| KC | 53.73 | 135.20 | .0057 | .1813 | 2.52 |
| IL-13 | 25.79 | 221.87 | .0151 | .4847 | 8.60 |
| MIG | 115.42 | 407.65 | .0155 | .4966 | 3.53 |
| MIP-2 | 6.57 | 15.40 | .0200 | .6401 | 2.34 |
| Cytokine . | Cdkn2a−/−Il10+/+ mice (pg/mL)* . | Cdkn2a−/−Il10−/− mice (pg/mL)* . | Nominal P . | Corrected P . | Fold change (relative to control) . |
|---|---|---|---|---|---|
| IL-6 | 6.49 | 98.12 | 1.098E-06 | 3.513E-05 | 15.12 |
| RANTES | 134.06 | 324.87 | 2.226E-06 | 7.123E-05 | 2.42 |
| G-CSF | 210.69 | 3762.93 | 3.526E-06 | .0001 | 17.86 |
| MCP-1 | 197.09 | 570.07 | 4.716E-06 | .0002 | 2.89 |
| IL-17A | 11.68 | 106.88 | 8.679E-06 | .0003 | 9.15 |
| IL-12p40 | 1155.44 | 3178.86 | 1.701E-05 | .0005 | 2.75 |
| MIP-1β | 17.70 | 54.20 | 4.850E-05 | .0016 | 3.06 |
| IFN-γ | 9.20 | 53.65 | 6.343E-05 | .0020 | 5.83 |
| IL-3 | 1.64 | 6.57 | 6.831E-05 | .0022 | 4.00 |
| IL-1β | 2.02 | 5.43 | .0001 | .0034 | 2.69 |
| GM-CSF | 72.45 | 179.37 | .0003 | .0111 | 2.48 |
| IL-5 | 2.08 | 24.29 | .0004 | .0113 | 11.68 |
| TNF-α | 18.62 | 70.41 | .0006 | .0201 | 3.78 |
| MIP-1α | 3.96 | 8.80 | .0008 | .0261 | 2.22 |
| IL-1α | 19.88 | 45.34 | .0012 | .0389 | 2.28 |
| IL-9 | 3.66 | 23.98 | .0022 | .0705 | 6.55 |
| IL-12p70 | 39.63 | 83.49 | .0037 | .1193 | 2.11 |
| KC | 53.73 | 135.20 | .0057 | .1813 | 2.52 |
| IL-13 | 25.79 | 221.87 | .0151 | .4847 | 8.60 |
| MIG | 115.42 | 407.65 | .0155 | .4966 | 3.53 |
| MIP-2 | 6.57 | 15.40 | .0200 | .6401 | 2.34 |
Eight- to 12-week-old Cdkn2a−/−Il10+/+ and Cdkn2a−/−Il10−/− mice were housed in a specific pathogen–free facility and matched for age and sex. Statistical tests used are described in Methods. P values < .05 are in bold.
Median cytokine concentrations.