Univariate analysis comparing cytokine profiles of 6 Il10+/+ controls and 10 Il10−/− mice
| Cytokine . | Il10+/+ mice (pg/mL)* . | Il10−/− mice (pg/mL)* . | Nominal P . | Corrected P . | Fold change (relative to control) . |
|---|---|---|---|---|---|
| IL-1α | 11.19 | 50.06 | 7.094E-07 | 2.27E-05 | 4.48 |
| IL12p40 | 710.07 | 2953.65 | 3.705E-06 | .0001 | 4.16 |
| G-CSF | 119.80 | 5738.25 | 4.653E-06 | .0001 | 47.90 |
| IL-6 | 12.21 | 131.50 | .0002 | .0056 | 10.77 |
| MIP-1β | 8.14 | 37.47 | .0003 | .0098 | 4.60 |
| IL-17A | 20.71 | 46.49 | .0011 | .0349 | 2.24 |
| M-CSF | 5945.67 | 7082.69 | .0017 | .0545 | 1.19 |
| IL-13 | 37.17 | 238.62 | .0039 | .1260 | 6.42 |
| Cytokine . | Il10+/+ mice (pg/mL)* . | Il10−/− mice (pg/mL)* . | Nominal P . | Corrected P . | Fold change (relative to control) . |
|---|---|---|---|---|---|
| IL-1α | 11.19 | 50.06 | 7.094E-07 | 2.27E-05 | 4.48 |
| IL12p40 | 710.07 | 2953.65 | 3.705E-06 | .0001 | 4.16 |
| G-CSF | 119.80 | 5738.25 | 4.653E-06 | .0001 | 47.90 |
| IL-6 | 12.21 | 131.50 | .0002 | .0056 | 10.77 |
| MIP-1β | 8.14 | 37.47 | .0003 | .0098 | 4.60 |
| IL-17A | 20.71 | 46.49 | .0011 | .0349 | 2.24 |
| M-CSF | 5945.67 | 7082.69 | .0017 | .0545 | 1.19 |
| IL-13 | 37.17 | 238.62 | .0039 | .1260 | 6.42 |
Eight- to 12-week-old Il10+/+ and Il10−/− mice were housed in a specific pathogen–free facility and matched for age and sex. Statistical tests used are described in Methods. P values < .05 are in bold.
M-CSF, macrophage colony-stimulating factor.
Median cytokine concentrations.