The incidence and kinetics of CRS and ICANS during mCD19 CAR T-cell therapy
| Patient . | CRS grade . | Onset of CRS (d) . | Resolution of CRS (d) . | CRS-specific symptoms . | ICANS grade . | Onset of ICANS (d) . | Resolution of ICANS (d) . | ICANS-specific symptom . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fever* . | Hypotension† . | Hypoxia‡ . | Depressed level of consciousness . | Seizure . | Elevated ICP/cerebral edema . | |||||||
| P1 | III | 2 | 8 | Yes | IV fluids | High-flow | NA | NA | NA | NA | NA | NA |
| P2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P3 | III | 1 | 9 | Yes | 1 vasopressor | Low-flow | I | 7 | 4 | Awaken spontaneously | No | No |
| P4 | I | 3 | 9 | Yes | No | No | NA | NA | NA | NA | NA | NA |
| P5 | III | 1 | 9 | Yes | IV fluids | High-flow | NA | NA | NA | NA | NA | NA |
| P6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P7 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P8 | I | 3 | 2 | Yes | No | No | NA | NA | NA | NA | NA | NA |
| P9 | I | 1 | 10 | Yes | No | No | NA | NA | NA | NA | NA | NA |
| P10 | III | 2 | 10 | Yes | IV fluids | High-flow | NA | NA | NA | NA | NA | NA |
| P11 | II | 1 | 10 | Yes | IV fluids | No | III | 7 | 10 | Awaken to voice | No | Local edema |
| P12 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P13 | III | 0 | 8 | Yes | 1 vasopressor | Low-flow | NA | NA | NA | NA | NA | NA |
| P14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P15 | I | 1 | 7 | Yes | No | No | I | 5 | 3 | Awaken spontaneously | No | No |
| P16 | I | 0 | 9 | Yes | No | No | I | 5 | 5 | Awaken spontaneously | No | No |
| P17 | II | 5 | 2 | Yes | IV fluids | No | III | 5 | 10 | Awaken spontaneously | Yes | Elevated ICP |
| P18 | III | 0 | 17 | Yes | 1 vasopressor | Low-flow | III | 10 | 6 | Awaken spontaneously | Yes | Elevated ICP |
| P19 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P20 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P21 | III | 0 | 12 | Yes | 1 vasopressor | Low-flow | III | 6 | 6 | Awaken to voice | Yes | Elevated ICP |
| P22 | III | 0 | 10 | Yes | 1 vasopressor | Low-flow | III | 6 | 5 | Awaken spontaneously | Yes | Elevated ICP |
| P23 | I | 3 | 5 | Yes | No | No | NA | NA | NA | NA | NA | NA |
| Patient . | CRS grade . | Onset of CRS (d) . | Resolution of CRS (d) . | CRS-specific symptoms . | ICANS grade . | Onset of ICANS (d) . | Resolution of ICANS (d) . | ICANS-specific symptom . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fever* . | Hypotension† . | Hypoxia‡ . | Depressed level of consciousness . | Seizure . | Elevated ICP/cerebral edema . | |||||||
| P1 | III | 2 | 8 | Yes | IV fluids | High-flow | NA | NA | NA | NA | NA | NA |
| P2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P3 | III | 1 | 9 | Yes | 1 vasopressor | Low-flow | I | 7 | 4 | Awaken spontaneously | No | No |
| P4 | I | 3 | 9 | Yes | No | No | NA | NA | NA | NA | NA | NA |
| P5 | III | 1 | 9 | Yes | IV fluids | High-flow | NA | NA | NA | NA | NA | NA |
| P6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P7 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P8 | I | 3 | 2 | Yes | No | No | NA | NA | NA | NA | NA | NA |
| P9 | I | 1 | 10 | Yes | No | No | NA | NA | NA | NA | NA | NA |
| P10 | III | 2 | 10 | Yes | IV fluids | High-flow | NA | NA | NA | NA | NA | NA |
| P11 | II | 1 | 10 | Yes | IV fluids | No | III | 7 | 10 | Awaken to voice | No | Local edema |
| P12 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P13 | III | 0 | 8 | Yes | 1 vasopressor | Low-flow | NA | NA | NA | NA | NA | NA |
| P14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P15 | I | 1 | 7 | Yes | No | No | I | 5 | 3 | Awaken spontaneously | No | No |
| P16 | I | 0 | 9 | Yes | No | No | I | 5 | 5 | Awaken spontaneously | No | No |
| P17 | II | 5 | 2 | Yes | IV fluids | No | III | 5 | 10 | Awaken spontaneously | Yes | Elevated ICP |
| P18 | III | 0 | 17 | Yes | 1 vasopressor | Low-flow | III | 10 | 6 | Awaken spontaneously | Yes | Elevated ICP |
| P19 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P20 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| P21 | III | 0 | 12 | Yes | 1 vasopressor | Low-flow | III | 6 | 6 | Awaken to voice | Yes | Elevated ICP |
| P22 | III | 0 | 10 | Yes | 1 vasopressor | Low-flow | III | 6 | 5 | Awaken spontaneously | Yes | Elevated ICP |
| P23 | I | 3 | 5 | Yes | No | No | NA | NA | NA | NA | NA | NA |
NA, not applicable; IV, intravenous.
Fever defined as temperature ≥38°C not attributable to any other cause.
Hypotension responding to IV fluids or managed with 1 or multiple vasopressors.
Hypoxia requiring supplemental oxygen (low flow ≤6 L/min nasal cannula or blow-by, high flow oxygen, or positive pressure).