These data describe only the first occurrences of a major morbidity and document the steadily increasing frequency of patients who have had the first occurrence of a major morbidity. Recurrent major morbidities are not addressed. These data are also presented in Figure 2 to illustrate the initial occurrence of major morbidities across all ages and the duration of subsequent follow-up after the initial major morbidity. These data do not include the 9 patients who died in their first days after birth and the 5 patients for whom no follow-up was reported. The initial occurrence of a major morbidity and the subsequent clinical course of each the 73 patients are reported in supplemental Table 4.

Age of patients at the time of their first occurrence of a major morbidity. The percent is the fraction of all patients with continued follow-up at each age.

Age of patients at the time of the first occurrence of a major morbidity plus patients who had a previous major morbidity and continued to survive and be observed.

The frequency of major morbidities among all patients who continued to be observed at each decade of age, calculated from columns 3 and 4.