Table 1.

Secreted molecules that have an effect on BM MKs

MoleculeTypeEffectReferences
CCL5 Cytokine Positive bias in myeloid cell production 62-64  
CXCL12 Cytokine Regulates the spatial distribution of MKs in the BM 69-70  
CXCL4 Cytokine Negatively promotes HSC proliferation 45, 50, 51  
IL-1α Cytokine TPO-independent differentiator of MKs 67-68  
PAF Lipid Affects the growth of human myeloid and erythroid progenitors 81-82  
PtdIns3P Lipid Involved in DMS formation 79  
S1P Lipid Involved in MK differentiation and proplatelet formation 85  
TGF-β1 Cytokine Maintains HSC quiescence 47  
TNF Cytokine Rapid maturation of SL-MkPs and MkPs 5  
TPO Cytokine Regulates MK differentiation from HSCs 8,10  
MoleculeTypeEffectReferences
CCL5 Cytokine Positive bias in myeloid cell production 62-64  
CXCL12 Cytokine Regulates the spatial distribution of MKs in the BM 69-70  
CXCL4 Cytokine Negatively promotes HSC proliferation 45, 50, 51  
IL-1α Cytokine TPO-independent differentiator of MKs 67-68  
PAF Lipid Affects the growth of human myeloid and erythroid progenitors 81-82  
PtdIns3P Lipid Involved in DMS formation 79  
S1P Lipid Involved in MK differentiation and proplatelet formation 85  
TGF-β1 Cytokine Maintains HSC quiescence 47  
TNF Cytokine Rapid maturation of SL-MkPs and MkPs 5  
TPO Cytokine Regulates MK differentiation from HSCs 8,10  

DMS, demarcation membrane system; IL-1α, interleukin-1α; PtdIns3P, phosphatidylinositol 3-monophosphate; TNF, tumor necrosis factor.

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