Table 1. Characteristics of patients... | American Society of Hematology

Table 1.

Characteristics of patients with DOS with hematopoietic malignancies

Case	Cancer	Age at diagnosis, y	DNMT3A variant	Variant in COSMIC	Cooperating mutations	Transplant	Alive	Years since diagnosis
1	AML	12	R882C	Yes	NPMc NF1^2505fsMYC^P72PT	No	Yes	6.5
2	B-ALL	9	R882H	Yes	Unknown	No	Yes	6.5
3*	Metastatic ganglioneuroblastoma posttherapy T-lymphoblastic leukemia	1.6 (GN) 6 (T-ALL)	R882H	Yes	Unknown	No	No	N/A
4†	Chronic multilineage cytopenias	5	Y528X	No	Unknown	No	Yes	4
5	AML	20	I310F	No	Unknown	Allogeneic	Yes	2.5
6	Hodgkin lymphoma	27	Y735C	No	Unknown	Autologous	Yes	5.5
7	Essential thrombocytosis	34	R882H	Yes	Unknown	No	No	N/A
8*	AML	15	R882C	Yes	PTPN11^T73I	No	Yes	8
9*	AML	12	Y735S	Yes	Unknown	No	Yes	12

Case	Cancer	Age at diagnosis, y	DNMT3A variant	Variant in COSMIC	Cooperating mutations	Transplant	Alive	Years since diagnosis
1	AML	12	R882C	Yes	NPMc NF1^2505fsMYC^P72PT	No	Yes	6.5
2	B-ALL	9	R882H	Yes	Unknown	No	Yes	6.5
3*	Metastatic ganglioneuroblastoma posttherapy T-lymphoblastic leukemia	1.6 (GN) 6 (T-ALL)	R882H	Yes	Unknown	No	No	N/A
4†	Chronic multilineage cytopenias	5	Y528X	No	Unknown	No	Yes	4
5	AML	20	I310F	No	Unknown	Allogeneic	Yes	2.5
6	Hodgkin lymphoma	27	Y735C	No	Unknown	Autologous	Yes	5.5
7	Essential thrombocytosis	34	R882H	Yes	Unknown	No	No	N/A
8*	AML	15	R882C	Yes	PTPN11^T73I	No	Yes	8
9*	AML	12	Y735S	Yes	Unknown	No	Yes	12

B-ALL, B-cell acute lymphoblastic leukemia; N/A, not applicable.

Previously reported.

Not a definite malignancy.