Table 2. Summary of the metabolomic... | American Society of Hematology

Table 2.

Summary of the metabolomic differences for use as a diagnostic biomarker

Name	Type of metabolite	Onset of cGVHD compared with the entire population at onset
		Mixed-effect multi-regression analysis (all time points) (Figure 4)	Mixed-effect multi-regression analysis moderate to severe supplemental (Figure 1)	Fixed-effect multi-regression analysis			Prepubertal (Figure 6A)	Pubertal (Figure 6B)
				Onset ≤120 days (Figure 5B)	Onset 121 to 240 days (Figure 5C)	Onset >240 days (Figure 5D)	Prepubertal (Figure 6A)	Pubertal (Figure 6B)
α-ketoglutaric	Organic acids	+++	+++	+	+	++	++ (EF = 1.26)	+
Citric acid						--	---
Glutamine						---
Betaine						-
p-Hydroxyhippuric acid		--	--	-		-		--
Arginine	Amino acids			-
Glutamic acid	Amino acids			++		+
Kynurenine	Amino acid-related	+++	+++	++		++		+++
Methylhistidine						+
Methionine-sulfoxide					++
Asymmetric dimethylarginine					+++
PC36:6AA	Phosphatidyl cholines		+++
C9	Medium-chain fatty acids	---	---	--			---
C10:1	Medium-chain fatty acids						---
Acetyl-ornithine	Biogenic amine	----	-				-	--
Spermidine		+++	+++		++		+++
18:0SM	Sphingolipid					++

Name	Type of metabolite	Onset of cGVHD compared with the entire population at onset
		Mixed-effect multi-regression analysis (all time points) (Figure 4)	Mixed-effect multi-regression analysis moderate to severe supplemental (Figure 1)	Fixed-effect multi-regression analysis			Prepubertal (Figure 6A)	Pubertal (Figure 6B)
				Onset ≤120 days (Figure 5B)	Onset 121 to 240 days (Figure 5C)	Onset >240 days (Figure 5D)	Prepubertal (Figure 6A)	Pubertal (Figure 6B)
α-ketoglutaric	Organic acids	+++	+++	+	+	++	++ (EF = 1.26)	+
Citric acid						--	---
Glutamine						---
Betaine						-
p-Hydroxyhippuric acid		--	--	-		-		--
Arginine	Amino acids			-
Glutamic acid	Amino acids			++		+
Kynurenine	Amino acid-related	+++	+++	++		++		+++
Methylhistidine						+
Methionine-sulfoxide					++
Asymmetric dimethylarginine					+++
PC36:6AA	Phosphatidyl cholines		+++
C9	Medium-chain fatty acids	---	---	--			---
C10:1	Medium-chain fatty acids						---
Acetyl-ornithine	Biogenic amine	----	-				-	--
Spermidine		+++	+++		++		+++
18:0SM	Sphingolipid					++

+, P ≤ .05; ++, P ≤ .001; +++, P ≤ .0001; –, P ≤ .05; ––, P ≤ .001; –––, P ≤ .0001.

EF, effect ratio.