Minimal common regions (<3 Mb) identified in MF and Sz
| Cytogenetic band . | Copy number alteration . | Start . | End . | Size . | Cancer gene (NCG 5.0) . | Affected MF patients (%)51 . | Affected Sz patients (%)14 . | Start . | End . | Size . |
|---|---|---|---|---|---|---|---|---|---|---|
| 9p21.3 | Loss | 21955000 | 21972000 | 17 kb | CDKN2A | 7 (78) | 3 (7.5) | 21958139 | 21998921 | 40 kb |
| 9q21.32 | Loss | 85800000 | 86650000 | 850 kb | KIF27, HNRNPK | 5 (56) | n.a. | |||
| 16p13.13 | Loss | 11050000 | 11355000 | 305 kb | SOCS1 | 5 (56) | n.a. | |||
| 1q31.3 | Loss | 198450000 | 198625488 | 175 kb | PTPRC | 4 (44) | n.a. | |||
| 13q14.3 | Loss | 50592381 | 51460719 | 868 kb | DLEU2/Mir-15a/16-1 locus | 4 (44) | n.a. | |||
| 1p36.11 | Loss | 26535118 | 27718137 | 1.2 Mb | ARID1A | 3 (33) | 7 (17.5) | 25163521 | 27933295 | 2.8 Mb |
| 10q23.31 | Loss | 89450000 | 90000000 | 550 kb | PTEN | 3 (33) | 2 (5) | 88803044 | 90764142 | 2.9 Mb |
| 10q23.33-10q24.1 | Loss | 96500000 | 97250000 | 750 kb | CYP2C9 | 3 (33) | n.a. | |||
| 9q21.31 | Loss | 81840000 | 82200000 | 360 kb | TLE4 | 3 (33) | n.a. | |||
| 20q13.13 | Loss | 48700000 | 50154295 | 1.4 Mb | PTPN1, PARD6B | 3 (33) | n.a. | |||
| 19p13.3 | Loss | 250000 | 2150000 | 1.9 Mb | C2CD4C, FSTL3, ABCA7, STK11, C19orf26, TCF3 | 3 (33) | 3 (7.5) | 232372 | 1597438 | 1.3 Mb |
| 5q15-5q21.1 | Loss | 96700000 | 98250000 | 1.5 Mb | CHD1 | 2 (22) | n.a. | |||
| 6p22.3-6p23 | Loss | 14200000 | 16750000 | 2.5 Mb | JARID2 | 2 (22) | 1 (5) | 152243466 | 152552262 | 9 kb |
| 13q14.11 | Loss | 40300000 | 41550000 | 1.2 Mb | FOXO1, MRPS31 | 2 (22) | 1 (5) | 40413041 | 42256311 | 43 kb |
| 16q24.3 | Loss | 88950000 | 89500000 | 550 kb | CBFA2T3, ANKRD11 | 2 (22) | n.a. | |||
| 5p13.3 | Gain | 32100000 | 32165000 | 65 kb | 3 (33) | n.a. | ||||
| 8q24.21 | Gain | 128747500 | 128757400 | 9.9 kb | MYC | 2 (22) | n.a. | |||
| 13q33.3-13q34 | Gain | 109350000 | 112250000 | 2.9 Mb | COL4A2 | 2 (22) | n.a. |
| Cytogenetic band . | Copy number alteration . | Start . | End . | Size . | Cancer gene (NCG 5.0) . | Affected MF patients (%)51 . | Affected Sz patients (%)14 . | Start . | End . | Size . |
|---|---|---|---|---|---|---|---|---|---|---|
| 9p21.3 | Loss | 21955000 | 21972000 | 17 kb | CDKN2A | 7 (78) | 3 (7.5) | 21958139 | 21998921 | 40 kb |
| 9q21.32 | Loss | 85800000 | 86650000 | 850 kb | KIF27, HNRNPK | 5 (56) | n.a. | |||
| 16p13.13 | Loss | 11050000 | 11355000 | 305 kb | SOCS1 | 5 (56) | n.a. | |||
| 1q31.3 | Loss | 198450000 | 198625488 | 175 kb | PTPRC | 4 (44) | n.a. | |||
| 13q14.3 | Loss | 50592381 | 51460719 | 868 kb | DLEU2/Mir-15a/16-1 locus | 4 (44) | n.a. | |||
| 1p36.11 | Loss | 26535118 | 27718137 | 1.2 Mb | ARID1A | 3 (33) | 7 (17.5) | 25163521 | 27933295 | 2.8 Mb |
| 10q23.31 | Loss | 89450000 | 90000000 | 550 kb | PTEN | 3 (33) | 2 (5) | 88803044 | 90764142 | 2.9 Mb |
| 10q23.33-10q24.1 | Loss | 96500000 | 97250000 | 750 kb | CYP2C9 | 3 (33) | n.a. | |||
| 9q21.31 | Loss | 81840000 | 82200000 | 360 kb | TLE4 | 3 (33) | n.a. | |||
| 20q13.13 | Loss | 48700000 | 50154295 | 1.4 Mb | PTPN1, PARD6B | 3 (33) | n.a. | |||
| 19p13.3 | Loss | 250000 | 2150000 | 1.9 Mb | C2CD4C, FSTL3, ABCA7, STK11, C19orf26, TCF3 | 3 (33) | 3 (7.5) | 232372 | 1597438 | 1.3 Mb |
| 5q15-5q21.1 | Loss | 96700000 | 98250000 | 1.5 Mb | CHD1 | 2 (22) | n.a. | |||
| 6p22.3-6p23 | Loss | 14200000 | 16750000 | 2.5 Mb | JARID2 | 2 (22) | 1 (5) | 152243466 | 152552262 | 9 kb |
| 13q14.11 | Loss | 40300000 | 41550000 | 1.2 Mb | FOXO1, MRPS31 | 2 (22) | 1 (5) | 40413041 | 42256311 | 43 kb |
| 16q24.3 | Loss | 88950000 | 89500000 | 550 kb | CBFA2T3, ANKRD11 | 2 (22) | n.a. | |||
| 5p13.3 | Gain | 32100000 | 32165000 | 65 kb | 3 (33) | n.a. | ||||
| 8q24.21 | Gain | 128747500 | 128757400 | 9.9 kb | MYC | 2 (22) | n.a. | |||
| 13q33.3-13q34 | Gain | 109350000 | 112250000 | 2.9 Mb | COL4A2 | 2 (22) | n.a. |