Cardiopulmonary and blood analyses of experimental mice
| . | Baseline . | Post-TBI (3 h) . | ||||
|---|---|---|---|---|---|---|
| . | TBI . | TBI ANV-6L15 . | Sham . | TBI . | TBI ANV-6L15 . | Sham . |
| Body temperature (°C) | 37.5 ± 0.3 | 37.5 ± 0.3 | 37.5 ± 0.3 | 36.5 ± 0.3 | 36.4 ± 0.4 | 37.2 ± 0.3 |
| Systolic BP (mmHg) | 107.5 ± 10.0 | 105.8 ± 6.9 | 107.8 ± 9.0 | 169.8 ± 16.3 | 139.7 ± 8.3 | 107.0 ± 4.6† |
| Diastolic BP (mmHg) | 84.2 ± 10.9 | 75.3 ± 6.8 | 78.2 ± 9.9 | 139.5 ± 10.6 | 89.5 ± 16.1 | 75.2 ± 12.8‡ |
| Heart rate (beats/min) | 444 ± 4 | 471 ± 20 | 448 ± 32 | 271 ± 21 | 356 ± 18 | 423 ± 27§ |
| *pO2 (mmHg) | 67.2 ± 8.7 | 64.3 ± 15.2 | 65.7 ± 14.0 | 30.0 ± 2.5 | 43.7 ± 3.8 | 52.8 ± 3.1ǁ |
| *pCO2 (mmHg) | 20.7 ± 4.4 | 24.4 ± 5.1 | 20.5 ± 4.4 | 52.4 ± 13.6 | 31.0 ± 4.6 | 24.5 ± 4.1¶ |
| pH | 7.2 ± 0.1 | 7.2 ± 0.1 | 7.2 ± 0.2 | 7.1 ± 0.2 | 7.3 ± 0.0 | 7.3 ± 0.1 |
| . | Baseline . | Post-TBI (3 h) . | ||||
|---|---|---|---|---|---|---|
| . | TBI . | TBI ANV-6L15 . | Sham . | TBI . | TBI ANV-6L15 . | Sham . |
| Body temperature (°C) | 37.5 ± 0.3 | 37.5 ± 0.3 | 37.5 ± 0.3 | 36.5 ± 0.3 | 36.4 ± 0.4 | 37.2 ± 0.3 |
| Systolic BP (mmHg) | 107.5 ± 10.0 | 105.8 ± 6.9 | 107.8 ± 9.0 | 169.8 ± 16.3 | 139.7 ± 8.3 | 107.0 ± 4.6† |
| Diastolic BP (mmHg) | 84.2 ± 10.9 | 75.3 ± 6.8 | 78.2 ± 9.9 | 139.5 ± 10.6 | 89.5 ± 16.1 | 75.2 ± 12.8‡ |
| Heart rate (beats/min) | 444 ± 4 | 471 ± 20 | 448 ± 32 | 271 ± 21 | 356 ± 18 | 423 ± 27§ |
| *pO2 (mmHg) | 67.2 ± 8.7 | 64.3 ± 15.2 | 65.7 ± 14.0 | 30.0 ± 2.5 | 43.7 ± 3.8 | 52.8 ± 3.1ǁ |
| *pCO2 (mmHg) | 20.7 ± 4.4 | 24.4 ± 5.1 | 20.5 ± 4.4 | 52.4 ± 13.6 | 31.0 ± 4.6 | 24.5 ± 4.1¶ |
| pH | 7.2 ± 0.1 | 7.2 ± 0.1 | 7.2 ± 0.2 | 7.1 ± 0.2 | 7.3 ± 0.0 | 7.3 ± 0.1 |
Data are presented as mean ± SEM and were analyzed using either ANOVA or Kruskal-Wallis ANOVA on ranks (n = 18).
pO2 and pCO2: partial pressures of oxygen and carbon dioxide (venous blood).
P < .001, sham vs TBI and TBI+ANV-6L15.
P < .001, sham vs TBI and TBI+ANV-6L15.
P < .05, sham vs TBI and TBI+ANV6L15.
P < .001 sham vs TBI and TBI+ANV-6L15.
P = .02 sham vs TBI and TBI+ANV-6L15.