Clinical and biological characteristics at baseline
| Characteristics . | Value . | Valid data (n) . |
|---|---|---|
| Total population, n (%) | 214 (100) | |
| Diagnosis period, n (%) | ||
| Diagnosis 2000-2005 | 50 (23.4) | 214 |
| Diagnosis 2006-2010 | 60 (28) | |
| Diagnosis 2011-2015 | 104 (48.6) | |
| Sex, n (%) | 214 | |
| Male | 137 (64) | |
| Female | 77 (36) | |
| Age, y | ||
| Median ± standard deviation | 37.2 ± 4.3 | |
| Minimum-maximum | 18.6-40.9 | |
| MGUS history, n (%) | 19 (9.2) | 206 |
| Type of disease, n (%) | 214 | |
| Symptomatic MM | 189 (88.3) | |
| pPCL | 9 (4.2) | |
| SMM | 10 (4.7) | |
| Solitary plasmacytoma | 4 (1.9) | |
| Randall disease | 2 (0.9) | |
| Isotype, n (%) | 213 | |
| Complete isotype | 162 (76) | |
| IgA | 28 (17.3) | |
| IgG | 130 (80.2) | |
| IgM | 1 (0.06) | |
| IgD | 3 (1.9) | |
| Light chain only | 51 (24) | |
| Light chain type, n (%) | 209 | |
| κ | 138 (66) | |
| λ | 71 (34) | |
| Bone lesions, n (%) | 149 (75) | 200 |
| Medical imaging, n (%)* | 190 | |
| Standard radiography | 100 (52.6) | |
| CT imaging | 64 (33.7) | |
| MRI | 114 (60) | |
| PET | 27 (14.2) | |
| None | 4 (2.1) | |
| Glomerular filtration rate (MDRD, ml/min), n (%) | 200 | |
| ≥60 | 166 (83) | |
| <60 | 34 (17) | |
| Hypercalcemia, n (%) | 195 | |
| >2.75 mmol/L | 25 (12.8) | |
| ≤2.75 mmol/L | 170 (87.2) | |
| Proteinuria >1 g/L, n (%) | 34 (22.7) | 150 |
| Albuminemia, median ± SD, g/L | 39.2 ± 8.2 | 187 |
| β2-Microglobulinemia, median ± SD, g/L | 2.83 ± 14.5 | 179 |
| Cytopenia, n (%) | ||
| Anemia (Hb <10 g/dL) | 71 (35.1) | 202 |
| Neutropenia (PNN <1.5 G/L) | 9 (4.7) | 193 |
| Thrombopenia (platelets <100 G/L) | 8 (4) | 199 |
| ISS score, n (%) | 189 | |
| 1 | 99 (52.4) | |
| 2 | 52 (27.5) | |
| 3 | 38 (20.1) | |
| Cytogenetics, n (%) | ||
| High risk, including*: | 34 (18) | 189 |
| t(4;14) | 19 (12.2) | 189 |
| del17p | 17 (12.1) | 156 |
| Others, including | 65 (34.4) | 141 |
| t(11;14) | 9 (25.7) | 189 |
| t(14;16) | 1 (2.5) | 35 |
| +1q† | 17 (30.4) | 39 |
| del1p32‡ | 8 (17.4) | 56 |
| Characteristics . | Value . | Valid data (n) . |
|---|---|---|
| Total population, n (%) | 214 (100) | |
| Diagnosis period, n (%) | ||
| Diagnosis 2000-2005 | 50 (23.4) | 214 |
| Diagnosis 2006-2010 | 60 (28) | |
| Diagnosis 2011-2015 | 104 (48.6) | |
| Sex, n (%) | 214 | |
| Male | 137 (64) | |
| Female | 77 (36) | |
| Age, y | ||
| Median ± standard deviation | 37.2 ± 4.3 | |
| Minimum-maximum | 18.6-40.9 | |
| MGUS history, n (%) | 19 (9.2) | 206 |
| Type of disease, n (%) | 214 | |
| Symptomatic MM | 189 (88.3) | |
| pPCL | 9 (4.2) | |
| SMM | 10 (4.7) | |
| Solitary plasmacytoma | 4 (1.9) | |
| Randall disease | 2 (0.9) | |
| Isotype, n (%) | 213 | |
| Complete isotype | 162 (76) | |
| IgA | 28 (17.3) | |
| IgG | 130 (80.2) | |
| IgM | 1 (0.06) | |
| IgD | 3 (1.9) | |
| Light chain only | 51 (24) | |
| Light chain type, n (%) | 209 | |
| κ | 138 (66) | |
| λ | 71 (34) | |
| Bone lesions, n (%) | 149 (75) | 200 |
| Medical imaging, n (%)* | 190 | |
| Standard radiography | 100 (52.6) | |
| CT imaging | 64 (33.7) | |
| MRI | 114 (60) | |
| PET | 27 (14.2) | |
| None | 4 (2.1) | |
| Glomerular filtration rate (MDRD, ml/min), n (%) | 200 | |
| ≥60 | 166 (83) | |
| <60 | 34 (17) | |
| Hypercalcemia, n (%) | 195 | |
| >2.75 mmol/L | 25 (12.8) | |
| ≤2.75 mmol/L | 170 (87.2) | |
| Proteinuria >1 g/L, n (%) | 34 (22.7) | 150 |
| Albuminemia, median ± SD, g/L | 39.2 ± 8.2 | 187 |
| β2-Microglobulinemia, median ± SD, g/L | 2.83 ± 14.5 | 179 |
| Cytopenia, n (%) | ||
| Anemia (Hb <10 g/dL) | 71 (35.1) | 202 |
| Neutropenia (PNN <1.5 G/L) | 9 (4.7) | 193 |
| Thrombopenia (platelets <100 G/L) | 8 (4) | 199 |
| ISS score, n (%) | 189 | |
| 1 | 99 (52.4) | |
| 2 | 52 (27.5) | |
| 3 | 38 (20.1) | |
| Cytogenetics, n (%) | ||
| High risk, including*: | 34 (18) | 189 |
| t(4;14) | 19 (12.2) | 189 |
| del17p | 17 (12.1) | 156 |
| Others, including | 65 (34.4) | 141 |
| t(11;14) | 9 (25.7) | 189 |
| t(14;16) | 1 (2.5) | 35 |
| +1q† | 17 (30.4) | 39 |
| del1p32‡ | 8 (17.4) | 56 |
Number of patients is expressed in absolute value (n), whereas percentage (%) is calculated among valid data, after exclusion of ND and NA values. CT, computed tomography; Hb, hemoglobin; IgA, immunoglobulin A; MDRD, Modification of Diet in Renal Disease equation; MGUS, monoclonal gammopathy of unknown significance; MRI, magnetic resonance imaging; PET, positron emission tomography; PNN, polynuclear neutrophil; SD, standard deviation.
Two patients had t(4;14) and del17p. Failure of cytogenetic analysis was considered as nonvalid data.
Associated with high-risk cytogenetics in 5 patients.
Associated with high-risk cytogenetics in 2 patients; associated with +1q in 5 patients.