Univariable and multivariable analysis of PFS
| Variable . | Univariable analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Female or male sex | 0.47 | 0.15-1.44 | .18 | — | — | |
| Age | 1.02 | 0.96-1.09 | .53 | — | — | |
| Performance status 1-2/0 | 2.54 | 0.98-6.59 | .055 | 2.61 | 1.01-6.78 | .048 |
| Creatinine clearance ≤70/>70 mL/min | 0.65 | 0.20-2.06 | .46 | — | — | |
| β2 microglobulin pathologic/normal | 0.59 | 0.21-1.66 | .32 | — | — | |
| LDH pathologic/normal | 1.71 | 0.65-4.49 | .28 | — | — | |
| Bulky disease ≥5/<5 cm | 1.31 | 0.30-5.77 | .72 | — | — | |
| Advanced-stage Rai III-IV Binet C/others | 1.23 | 0.47-3.25 | .67 | — | — | |
| IGHV mutated/unmutated | 0.58 | 0.21-1.65 | .31 | — | — | |
| Complex karyotype, no/yes | 0.29 | 0.11-0.74 | .010 | 0.28 | 0.11-0.73 | .009 |
| Cytogenetics | ||||||
| Complex karyotype ≥5 | — | — | — | |||
| 1-2 lesions/normal/del13q | 0.37 | 0-10-1.38 | .14 | — | — | |
| 3-4 lesions/normal/del13q | 1.49 | 0.37-5.99 | .57 | — | — | |
| TP53 disruption yes/no | 1.82 | 0.64-5.18 | .26 | — | — | |
| TP53 and cytogenetics | ||||||
| No complex karyotype and TP53 WT | — | — | — | |||
| Complex karyotype and TP53 WT | 3.45 | 1.09-10.9 | .035 | — | — | |
| TP53 disruption | 2.58 | 0.82-8.14 | .11 | — | — | |
| Variable . | Univariable analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Female or male sex | 0.47 | 0.15-1.44 | .18 | — | — | |
| Age | 1.02 | 0.96-1.09 | .53 | — | — | |
| Performance status 1-2/0 | 2.54 | 0.98-6.59 | .055 | 2.61 | 1.01-6.78 | .048 |
| Creatinine clearance ≤70/>70 mL/min | 0.65 | 0.20-2.06 | .46 | — | — | |
| β2 microglobulin pathologic/normal | 0.59 | 0.21-1.66 | .32 | — | — | |
| LDH pathologic/normal | 1.71 | 0.65-4.49 | .28 | — | — | |
| Bulky disease ≥5/<5 cm | 1.31 | 0.30-5.77 | .72 | — | — | |
| Advanced-stage Rai III-IV Binet C/others | 1.23 | 0.47-3.25 | .67 | — | — | |
| IGHV mutated/unmutated | 0.58 | 0.21-1.65 | .31 | — | — | |
| Complex karyotype, no/yes | 0.29 | 0.11-0.74 | .010 | 0.28 | 0.11-0.73 | .009 |
| Cytogenetics | ||||||
| Complex karyotype ≥5 | — | — | — | |||
| 1-2 lesions/normal/del13q | 0.37 | 0-10-1.38 | .14 | — | — | |
| 3-4 lesions/normal/del13q | 1.49 | 0.37-5.99 | .57 | — | — | |
| TP53 disruption yes/no | 1.82 | 0.64-5.18 | .26 | — | — | |
| TP53 and cytogenetics | ||||||
| No complex karyotype and TP53 WT | — | — | — | |||
| Complex karyotype and TP53 WT | 3.45 | 1.09-10.9 | .035 | — | — | |
| TP53 disruption | 2.58 | 0.82-8.14 | .11 | — | — | |
HR, hazard ratio; LDH, lactate dehydrogenase.