Table 1. Risk group definitions Risk... | American Society of Hematology

Table 1.

Risk group definitions

Risk group	Criteria
Standard	Must meet all of the following: Day 8 good prednisone response* Negative t4;11 and/or KMT2A/AFF1 TP1 BM <5% leukemic blasts Precursor-B or T-cell phenotype MRD negative at TP1 and TP2
Medium	Must meet all of the following: Day 8 good prednisone response Negative t4;11 and/or KMT2A/AFF1 TP1 BM <5% leukemic blasts Precursor-B, pro-B, or T-cell phenotype MRD positive at TP1 and negative at TP2 or not tested/no result
Medium–high	Must meet all of the following: Day 8 good prednisone response Negative t4;11 and/or KMT2A/AFF1 TP1 BM <5% leukemic blasts Precursor-B or T-cell phenotype MRD does not meet criteria for SR, HR, or VHR. MRD positive at TP1 and positive at TP2 but must be <5 × 10⁻⁴
High	Must meet all of the following: Day 8 poor prednisone response† Precursor-B phenotype (not T- or pro-B) and presenting WCC <100 × 10⁹/L MRD positive at TP1 and positive at TP2 but must be <5 × 10⁻⁴ or not tested/no result
Very high	Any one or more of the following: TP2 MRD ≥5 × 10⁻⁴ Day 8 poor prednisone response and T-cell or pro-B phenotype or presenting WCC ≥100 × 10⁹/L Positive for t4;11 or KMT2A/AFF1 TP1 BM ≥5% leukemic blasts

Risk group	Criteria
Standard	Must meet all of the following: Day 8 good prednisone response* Negative t4;11 and/or KMT2A/AFF1 TP1 BM <5% leukemic blasts Precursor-B or T-cell phenotype MRD negative at TP1 and TP2
Medium	Must meet all of the following: Day 8 good prednisone response Negative t4;11 and/or KMT2A/AFF1 TP1 BM <5% leukemic blasts Precursor-B, pro-B, or T-cell phenotype MRD positive at TP1 and negative at TP2 or not tested/no result
Medium–high	Must meet all of the following: Day 8 good prednisone response Negative t4;11 and/or KMT2A/AFF1 TP1 BM <5% leukemic blasts Precursor-B or T-cell phenotype MRD does not meet criteria for SR, HR, or VHR. MRD positive at TP1 and positive at TP2 but must be <5 × 10⁻⁴
High	Must meet all of the following: Day 8 poor prednisone response† Precursor-B phenotype (not T- or pro-B) and presenting WCC <100 × 10⁹/L MRD positive at TP1 and positive at TP2 but must be <5 × 10⁻⁴ or not tested/no result
Very high	Any one or more of the following: TP2 MRD ≥5 × 10⁻⁴ Day 8 poor prednisone response and T-cell or pro-B phenotype or presenting WCC ≥100 × 10⁹/L Positive for t4;11 or KMT2A/AFF1 TP1 BM ≥5% leukemic blasts

Day 8 good prednisone response defined as PB blast count <1.0 × 10⁹/L after 7 days of prednisone and 1 intrathecal injection of methotrexate given on day 1.

†

Day 8 poor prednisone response defined as PB blast count ≥1.0 × 10⁹/L after 7 days of prednisone and 1 intrathecal injection of methotrexate given on day 1.

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