Univariable and multivariable Cox regression analyses of OS and TFS in discovery cohort
| Variable . | OS . | TFS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariable . | Multivariable . | Univariable . | Multivariable . | |||||
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Dominant canonical RAS mutation | ||||||||
| Other | 1 | 1 | 1 | |||||
| Somatic PTPN11 or NF1 | 1.87 (0.962-3.65) | .065 | 6.24 (3.50-11.1) | 5.61 × 10−10 | 4.94 (2.09-11.7) | 2.81 × 10−4 | ||
| ≥2 mutations | ||||||||
| No | 1 | 1 | ||||||
| Yes | 1.28 (0.581-2.82) | .541 | 2.44 (1.35-4.43) | 3.29 × 10−3 | ||||
| Methylation profile | ||||||||
| LM_DREAM | 1 | 1 | 1 | 1 | ||||
| HM_DREAM | 2.65 (1.35-5.24) | 4.88 × 10−3 | 1.95 (0.895-4.24) | .093 | 5.51 (3.09-9.83) | 7.19 × 10−9 | 9.41 (2.39-37.1) | 1.37 × 10−3 |
| Expression profile | ||||||||
| Non–AML-like | 1 | 1 | 1 | |||||
| AML-like | 1.39 (0.688-2.83) | .357 | 3.03 (1.65-5.57) | 3.42 × 10−4 | 0.440 (0.189-1.02) | .0569 | ||
| LIN28B expression | ||||||||
| No | 1 | 1 | 1 | |||||
| Yes | 1.52 (0.757-3.05) | .24 | 2.63 (1.51-4.59) | 6.82 × 10−4 | 0.280 (0.0939-0.833) | .0222 | ||
| Monosomy 7 | ||||||||
| No | 1 | 1 | 1 | |||||
| Yes | 3.47 (1.50-8.04) | 3.68 × 10−3 | 2.74 (1.06-7.09) | .037 | 3.21 (1.55-6.62) | 1.65 × 10−3 | ||
| Age at diagnosis, mo | ||||||||
| ≤24 | 1 | 1 | ||||||
| >24 | 2.20 (1.13-4.28) | .0201 | 2.40 (1.45-3.99) | 6.68 × 10−4 | ||||
| Elevated HbF level | ||||||||
| No | 1 | 1 | ||||||
| Yes | 2.28 (0.867-5.98) | .0949 | 2.29 (1.24-4.23) | 7.80 × 10−3 | ||||
| PLTs at diagnosis, ×109/L | ||||||||
| ≥33 | 1 | 1 | ||||||
| <33 | 1.78 (0.871-3.64) | .114 | 2.05 (1.20-3.50) | 8.30 × 10−3 | ||||
| Variable . | OS . | TFS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariable . | Multivariable . | Univariable . | Multivariable . | |||||
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Dominant canonical RAS mutation | ||||||||
| Other | 1 | 1 | 1 | |||||
| Somatic PTPN11 or NF1 | 1.87 (0.962-3.65) | .065 | 6.24 (3.50-11.1) | 5.61 × 10−10 | 4.94 (2.09-11.7) | 2.81 × 10−4 | ||
| ≥2 mutations | ||||||||
| No | 1 | 1 | ||||||
| Yes | 1.28 (0.581-2.82) | .541 | 2.44 (1.35-4.43) | 3.29 × 10−3 | ||||
| Methylation profile | ||||||||
| LM_DREAM | 1 | 1 | 1 | 1 | ||||
| HM_DREAM | 2.65 (1.35-5.24) | 4.88 × 10−3 | 1.95 (0.895-4.24) | .093 | 5.51 (3.09-9.83) | 7.19 × 10−9 | 9.41 (2.39-37.1) | 1.37 × 10−3 |
| Expression profile | ||||||||
| Non–AML-like | 1 | 1 | 1 | |||||
| AML-like | 1.39 (0.688-2.83) | .357 | 3.03 (1.65-5.57) | 3.42 × 10−4 | 0.440 (0.189-1.02) | .0569 | ||
| LIN28B expression | ||||||||
| No | 1 | 1 | 1 | |||||
| Yes | 1.52 (0.757-3.05) | .24 | 2.63 (1.51-4.59) | 6.82 × 10−4 | 0.280 (0.0939-0.833) | .0222 | ||
| Monosomy 7 | ||||||||
| No | 1 | 1 | 1 | |||||
| Yes | 3.47 (1.50-8.04) | 3.68 × 10−3 | 2.74 (1.06-7.09) | .037 | 3.21 (1.55-6.62) | 1.65 × 10−3 | ||
| Age at diagnosis, mo | ||||||||
| ≤24 | 1 | 1 | ||||||
| >24 | 2.20 (1.13-4.28) | .0201 | 2.40 (1.45-3.99) | 6.68 × 10−4 | ||||
| Elevated HbF level | ||||||||
| No | 1 | 1 | ||||||
| Yes | 2.28 (0.867-5.98) | .0949 | 2.29 (1.24-4.23) | 7.80 × 10−3 | ||||
| PLTs at diagnosis, ×109/L | ||||||||
| ≥33 | 1 | 1 | ||||||
| <33 | 1.78 (0.871-3.64) | .114 | 2.05 (1.20-3.50) | 8.30 × 10−3 | ||||
Patients with NS/MPD (n = 12) were excluded from survival analysis.
HbF, fetal hemoglobin; HR, hazard ratio; PLT, platelet.