Total therapies administered in patients with ES and relative responses
| . | Treatment administered . | |||
|---|---|---|---|---|
| Any cytopenia (n = 115) . | AIHA (n = 38) . | ITP (n = 40) . | ITP + AIHA (n = 37) . | |
| Steroids alone | ||||
| N of patients | 84 | 18 | 29 | 37 |
| ORR | 81/84 (96) | 17/18 (94) | 27/29 (93) | 37/37 (100) |
| Steroids + IVIGs | ||||
| N of patients | 42 | 3 | 29 | 10 |
| ORR | 39/42 (93) | 2/3 (67) | 27/29 (93) | 8/10 (80) |
| Rituximab | ||||
| N of patients | 46 | 23 | 10 | 13 |
| ORR | 44/46 (96) | 23/23 (100) | 8/10 (80) | 13/13 (100) |
| IST | ||||
| N of patients | 26 | 15 | 11 | — |
| ORR | 25/26 (96) | 15/15 (100) | 10/11 (91) | — |
| Eltrombopag | ||||
| N of patients | 19 | — | 19 | — |
| ORR | 18/19 (95) | — | 18/19 (95) | — |
| Romiplostim | ||||
| N of patients | 8 | — | 8 | — |
| ORR | 7/8 (88) | — | 7/8 (88) | — |
| Splenectomy | ||||
| N of patients | 12 | 7 | 5 | — |
| ORR | 12/12 (100) | 7/7 (100) | 5/5 (100) | — |
| Danazol | ||||
| N of patients | 5 | 3 | 2 | — |
| ORR | 5/5 (100) | 3/3 (100) | 2/2 (100) | — |
| . | Treatment administered . | |||
|---|---|---|---|---|
| Any cytopenia (n = 115) . | AIHA (n = 38) . | ITP (n = 40) . | ITP + AIHA (n = 37) . | |
| Steroids alone | ||||
| N of patients | 84 | 18 | 29 | 37 |
| ORR | 81/84 (96) | 17/18 (94) | 27/29 (93) | 37/37 (100) |
| Steroids + IVIGs | ||||
| N of patients | 42 | 3 | 29 | 10 |
| ORR | 39/42 (93) | 2/3 (67) | 27/29 (93) | 8/10 (80) |
| Rituximab | ||||
| N of patients | 46 | 23 | 10 | 13 |
| ORR | 44/46 (96) | 23/23 (100) | 8/10 (80) | 13/13 (100) |
| IST | ||||
| N of patients | 26 | 15 | 11 | — |
| ORR | 25/26 (96) | 15/15 (100) | 10/11 (91) | — |
| Eltrombopag | ||||
| N of patients | 19 | — | 19 | — |
| ORR | 18/19 (95) | — | 18/19 (95) | — |
| Romiplostim | ||||
| N of patients | 8 | — | 8 | — |
| ORR | 7/8 (88) | — | 7/8 (88) | — |
| Splenectomy | ||||
| N of patients | 12 | 7 | 5 | — |
| ORR | 12/12 (100) | 7/7 (100) | 5/5 (100) | — |
| Danazol | ||||
| N of patients | 5 | 3 | 2 | — |
| ORR | 5/5 (100) | 3/3 (100) | 2/2 (100) | — |
Values are given as n (%). N of patients requiring 1 line of therapy only, 26 (23%); 2 lines, 26 (23%); 3 lines, 30 (26%); >4 lines, 33 (28%). A 79-y-old man with chronic lymphocytic leukemia was not treated; his Hb level stabilized at ∼10 g/dL, and PLTs never dropped below 30 × 109/L.
ORR, overall response rate.