The most commonly mutated genes in CHIP/CCUS and their respective functions
| Genes . | Function/pathway . |
|---|---|
| DNMT3A, TET2, ASXL1, IDH1, IDH2 | Epigenetic regulators |
| SF3B1, SRSF2, U2AF1 | RNA splicing |
| TP53, PPM1D | DNA repair/cell cycle |
| JAK2, CBL, GNAS, GNB1 | Signaling |
| BCOR, BCORL1 | Transcription regulation |
| Genes . | Function/pathway . |
|---|---|
| DNMT3A, TET2, ASXL1, IDH1, IDH2 | Epigenetic regulators |
| SF3B1, SRSF2, U2AF1 | RNA splicing |
| TP53, PPM1D | DNA repair/cell cycle |
| JAK2, CBL, GNAS, GNB1 | Signaling |
| BCOR, BCORL1 | Transcription regulation |
Mutations in DNMT3A, TET2, and ASXL1 are the most frequent mutations in CHIP and confer a lower risk of progression in solitary.