Differential diagnosis of hypocellular marrow failure
| Acquired . | Inherited . |
|---|---|
| aAA | Classical IBMFS/MMP Fanconi anemia Short telomere syndromes Shwachman-Diamond Syndrome GATA2 deficiency SAMD9/SAMD9L disorders |
| Anorexia nervosa | |
| Hypocellular myelodysplastic syndrome | Inborn errors of immunity (eg, X-linked lymphoproliferative disorder) |
| Medications/toxins |
| Acquired . | Inherited . |
|---|---|
| aAA | Classical IBMFS/MMP Fanconi anemia Short telomere syndromes Shwachman-Diamond Syndrome GATA2 deficiency SAMD9/SAMD9L disorders |
| Anorexia nervosa | |
| Hypocellular myelodysplastic syndrome | Inborn errors of immunity (eg, X-linked lymphoproliferative disorder) |
| Medications/toxins |
This table is not exhaustive and is intended to capture the more commonly encounter entities that can present as aplastic anemia. In our clinical experience, the IBMFSs/MMPs listed here are not always characterized by hypocellular marrows. Gelatinous degradation of the bone marrow also may be seen in anorexia nervosa.2