Clinical categories of patients with PNH clones
| PNH category . | PNH granulocyte clone . | Clinical hemolysis . | Laboratory markers of hemolysis . | PNH symptoms . | Risk of thrombosis . | Utility of complement inhibitor therapy . |
|---|---|---|---|---|---|---|
| Bone marrow failure with an associated PNH clone | ||||||
| Subclinical (majority of patients) | Small (usually <30%) | Absent | May be present, depending on clone size | Absent | Low | Do not benefit from complement inhibitor |
| Symptomatic | Moderate | May be present | May be present | May be present | Intermediate | Some patients may benefit from complement inhibitor |
| Classical PNH | Large (usually >50%) | Present | Present | Present | High | Complement inhibitor improves outcomes |
| PNH category . | PNH granulocyte clone . | Clinical hemolysis . | Laboratory markers of hemolysis . | PNH symptoms . | Risk of thrombosis . | Utility of complement inhibitor therapy . |
|---|---|---|---|---|---|---|
| Bone marrow failure with an associated PNH clone | ||||||
| Subclinical (majority of patients) | Small (usually <30%) | Absent | May be present, depending on clone size | Absent | Low | Do not benefit from complement inhibitor |
| Symptomatic | Moderate | May be present | May be present | May be present | Intermediate | Some patients may benefit from complement inhibitor |
| Classical PNH | Large (usually >50%) | Present | Present | Present | High | Complement inhibitor improves outcomes |