Refined transplantation eligibility criteria across transplant centers
| Boston University, USA16 . | Mayo Clinic, USA18 . | National Amyloidosis Center, UK19 . |
|---|---|---|
| Cardiac ejection fraction ≥40% | Age ≤70 years | No symptomatic gastrointestinal involvement |
| Absence of symptomatic pleural effusions | Creatinine clearance ≥30 mL/min | Estimated glomerular filtration rate ≥45 mL/min |
| Absence of uncompensated heart failure or arrhythmias resistant to medical management | New York Health Association functional class I or II | No symptomatic cardiac involvement |
| Oxygen saturation ≥95% on room air | ≤2 Organs significantly involved | ≤2 Organs significantly involved |
| Lung diffusion capacity ≥50% predicted | Troponin T ≤ 0.06 ng/mL | High sensitivity troponin T ≤ 0.06 ng/mL |
| Supine systolic blood pressure ≥90 mm Hg | Systolic blood pressure ≥90 mm Hg | No autonomic neuropathy |
| Southwest Oncology Group performance status score ≤2 unless limited by peripheral neuropathy | Eastern Cooperative Oncology Group performance score ≤2 | Eastern Cooperative Oncology Group performance score ≤1 |
| Boston University, USA16 . | Mayo Clinic, USA18 . | National Amyloidosis Center, UK19 . |
|---|---|---|
| Cardiac ejection fraction ≥40% | Age ≤70 years | No symptomatic gastrointestinal involvement |
| Absence of symptomatic pleural effusions | Creatinine clearance ≥30 mL/min | Estimated glomerular filtration rate ≥45 mL/min |
| Absence of uncompensated heart failure or arrhythmias resistant to medical management | New York Health Association functional class I or II | No symptomatic cardiac involvement |
| Oxygen saturation ≥95% on room air | ≤2 Organs significantly involved | ≤2 Organs significantly involved |
| Lung diffusion capacity ≥50% predicted | Troponin T ≤ 0.06 ng/mL | High sensitivity troponin T ≤ 0.06 ng/mL |
| Supine systolic blood pressure ≥90 mm Hg | Systolic blood pressure ≥90 mm Hg | No autonomic neuropathy |
| Southwest Oncology Group performance status score ≤2 unless limited by peripheral neuropathy | Eastern Cooperative Oncology Group performance score ≤2 | Eastern Cooperative Oncology Group performance score ≤1 |