Comparison between simple and exchange transfusion
| . | Simple transfusion . | Exchange transfusion . |
|---|---|---|
| Description | • Infuse donor blood without removing patient's blood | • Remove patient's blood during or shortly before infusing donor blood • May be partial or total exchange • May be performed manually or via apheresis |
| Indication/recommendation | • Acute anemia • Acute complications (ie, ACS) with Hb | • Severe ACS failing to respond to simple transfusion • Acute complications with Hb ≥9 g/dL • Conditions requiring reduced HbS percentage (ie, stroke/stroke prevention |
| Potential risks and/or limitations | • Hyperviscosity • Iron overload | • Iron overload (less frequent than simple transfusion) • May require central venous catheter • Requires specialized equipment and trained staff • Costly (compared to simple transfusion |
| . | Simple transfusion . | Exchange transfusion . |
|---|---|---|
| Description | • Infuse donor blood without removing patient's blood | • Remove patient's blood during or shortly before infusing donor blood • May be partial or total exchange • May be performed manually or via apheresis |
| Indication/recommendation | • Acute anemia • Acute complications (ie, ACS) with Hb | • Severe ACS failing to respond to simple transfusion • Acute complications with Hb ≥9 g/dL • Conditions requiring reduced HbS percentage (ie, stroke/stroke prevention |
| Potential risks and/or limitations | • Hyperviscosity • Iron overload | • Iron overload (less frequent than simple transfusion) • May require central venous catheter • Requires specialized equipment and trained staff • Costly (compared to simple transfusion |