Indications for transfusion in SCD
| Indication . | Type of transfusion . |
|---|---|
| Acute transfusion indication | |
| Symptomatic anemia: aplastic crisis, acute splenic sequestration | Simple transfusion |
| Acute clinical stroke or TIA | Exchange transfusion |
| Acute hepatic sequestration/intrahepatic cholestasis | Simple or exchange transfusion |
| ACS | Simple or exchange transfusion |
| Acute multiorgan failure | Simple or exchange transfusion |
| Preoperative (surgeries lasting > 1 hour and require general anesthesia) | Simple or exchange transfusion |
| Pregnancy* | Simple or exchange transfusion |
| Chronic transfusion indication | |
| Primary stroke prevention | Simple or exchange transfusion |
| Secondary stroke prevention | Simple or exchange transfusion |
| Recurrent VOC | Simple or exchange transfusion |
| Indication . | Type of transfusion . |
|---|---|
| Acute transfusion indication | |
| Symptomatic anemia: aplastic crisis, acute splenic sequestration | Simple transfusion |
| Acute clinical stroke or TIA | Exchange transfusion |
| Acute hepatic sequestration/intrahepatic cholestasis | Simple or exchange transfusion |
| ACS | Simple or exchange transfusion |
| Acute multiorgan failure | Simple or exchange transfusion |
| Preoperative (surgeries lasting > 1 hour and require general anesthesia) | Simple or exchange transfusion |
| Pregnancy* | Simple or exchange transfusion |
| Chronic transfusion indication | |
| Primary stroke prevention | Simple or exchange transfusion |
| Secondary stroke prevention | Simple or exchange transfusion |
| Recurrent VOC | Simple or exchange transfusion |
Pregnant women with severe or frequent SCD-related complications or high-risk pregnancy.