Incidence of bleeding and portal vein thrombosis in CLD reported in prospective studies
| Study setting . | Study design . | Participants, n . | Child-Pugh class A, n (%) . | Incidence . |
|---|---|---|---|---|
| Bleeding | ||||
| Italy, 2012-20143 | Prospective, multicenter | 280 | 53 | Overall: 5.5%/year Major: 3.6%/year Minor: 1.9%/year Portal hypertensive: ~3.3%/year Nonvariceal GI: 1.9%/year Intracranial: 0.17%/year |
| United States, December 2009 to January 20104 | Prospective, single-center hospitalized cohort | 83 | 0 | Overall: 40% Variceal: 17% Nonvariceal GI: 12% |
| Portal vein thrombosis | ||||
| Italy, 2012-20145 | Prospective, multicenter | 753 | 397 (53) | 6.1/100 patient years |
| No PVT at enrollment | 692 | 4.1 | ||
| Prior PVT at enrollment | 61 | 18.9 | ||
| France/Belgium, 2000-20066 | Prospective, multicenter | 1243 | 863 (69) | 1 y: 4.6% Cumulative 5 y: 10.7% |
| France, 2014-20177 | Prospective, single center | 108 | 75 (77) | 1 y: 10.8% |
| Portugal, 2014-20198 | Prospective, single center | 241 | 184 (76) | 1 y: 3.7% Cumulative 3 y: 7.6% |
| Study setting . | Study design . | Participants, n . | Child-Pugh class A, n (%) . | Incidence . |
|---|---|---|---|---|
| Bleeding | ||||
| Italy, 2012-20143 | Prospective, multicenter | 280 | 53 | Overall: 5.5%/year Major: 3.6%/year Minor: 1.9%/year Portal hypertensive: ~3.3%/year Nonvariceal GI: 1.9%/year Intracranial: 0.17%/year |
| United States, December 2009 to January 20104 | Prospective, single-center hospitalized cohort | 83 | 0 | Overall: 40% Variceal: 17% Nonvariceal GI: 12% |
| Portal vein thrombosis | ||||
| Italy, 2012-20145 | Prospective, multicenter | 753 | 397 (53) | 6.1/100 patient years |
| No PVT at enrollment | 692 | 4.1 | ||
| Prior PVT at enrollment | 61 | 18.9 | ||
| France/Belgium, 2000-20066 | Prospective, multicenter | 1243 | 863 (69) | 1 y: 4.6% Cumulative 5 y: 10.7% |
| France, 2014-20177 | Prospective, single center | 108 | 75 (77) | 1 y: 10.8% |
| Portugal, 2014-20198 | Prospective, single center | 241 | 184 (76) | 1 y: 3.7% Cumulative 3 y: 7.6% |
Modified from Roberts and Bernal (2020)2 with permission from Thieme.