Table 3. Prognostic risk factors in... | American Society of Hematology

Table 3.

Prognostic risk factors in advanced phase CML

Characteristic	Poor risk factors
Clinical^13,14	Blast % (most important prognostic indicator, greater impact in AP compared with BP) Older age Anemia Thrombocytopenia Basophil % Prior TKI Myeloid immunophenotype
Chromosomal^13,15-17	+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q, complex, del17p, hyperdiploidy, chromosome 15 abnormalities
Molecular^15,18	TP53 ASXL1 Acquisition of new mutations during TKI treatment (ABL1 kinase mutations, TP53, KMT2D, TET2)

Characteristic	Poor risk factors
Clinical^13,14	Blast % (most important prognostic indicator, greater impact in AP compared with BP) Older age Anemia Thrombocytopenia Basophil % Prior TKI Myeloid immunophenotype
Chromosomal^13,15-17	+8, +Ph, i(17q), +17, +19, +21, 3q26.2, 11q23, −7/7q, complex, del17p, hyperdiploidy, chromosome 15 abnormalities
Molecular^15,18	TP53 ASXL1 Acquisition of new mutations during TKI treatment (ABL1 kinase mutations, TP53, KMT2D, TET2)