A practical guide for adopting PK assessment in the clinic
| Question . | Answer . |
|---|---|
| How should I schedule the clinic visit? | Time/day of infusion and clinic visit should be coordinated to ensure factor levels can be drawn at required time points to minimize multiple patient visits and inconvenience |
| What are the ideal measurement time points?* | For SHL FVIII – predose, 2-4 hours, 24 ± 4 hours, 48 ± 6 hours; for SHL FIX – predose, any time on day 2 and 3; for EHL – as above and add a time point at 60-84 hours for FVIII and at 2-14 days for FIX |
| What population PK software is available? | A globally accessible online tool, such as WAPPS-Hemo, or product-specific tools by the product manufacturers |
| What information is required?* | Age, baseline factor level, product name, total dose administered, body weight, height, infusion day, infusion time, postinfusion factor levels, and timing of samples |
| What do I do with the results? | Share and explain results with patients/caregivers; tailor treatment regimen based on results, if appropriate; integrate results into patient's medical records |
| Question . | Answer . |
|---|---|
| How should I schedule the clinic visit? | Time/day of infusion and clinic visit should be coordinated to ensure factor levels can be drawn at required time points to minimize multiple patient visits and inconvenience |
| What are the ideal measurement time points?* | For SHL FVIII – predose, 2-4 hours, 24 ± 4 hours, 48 ± 6 hours; for SHL FIX – predose, any time on day 2 and 3; for EHL – as above and add a time point at 60-84 hours for FVIII and at 2-14 days for FIX |
| What population PK software is available? | A globally accessible online tool, such as WAPPS-Hemo, or product-specific tools by the product manufacturers |
| What information is required?* | Age, baseline factor level, product name, total dose administered, body weight, height, infusion day, infusion time, postinfusion factor levels, and timing of samples |
| What do I do with the results? | Share and explain results with patients/caregivers; tailor treatment regimen based on results, if appropriate; integrate results into patient's medical records |
Ideal time points and information required are based on WAPPS-Hemo (www.wapps-hemo.org). Please see product manufacturers' manual if using product-specific tools. Adapted with permission from Hermans C, Dolan G. Therapeutic Advances in Hematology (Volume 11).66 © The Author(s), 2020; Reprinted by Permission of SAGE Publications.