Association of bleeding manifestations with severity of disease based on plasma clotting factor levels
| Severity . | Plasma clotting factor levels . | Bleeding manifestations . |
|---|---|---|
| Mild | 5%-<40% of normal | Bleeding with major trauma or surgery; rare spontaneous bleeding |
| Moderate | 1%-5% of normal | Bleeding with minor trauma or surgery; occasional spontaneous bleeding |
| Severe | <1% of normal | Spontaneous bleeding predominantly in the joints or muscles but can occur anywhere, including life-threatening intracranial bleed |
| Severity . | Plasma clotting factor levels . | Bleeding manifestations . |
|---|---|---|
| Mild | 5%-<40% of normal | Bleeding with major trauma or surgery; rare spontaneous bleeding |
| Moderate | 1%-5% of normal | Bleeding with minor trauma or surgery; occasional spontaneous bleeding |
| Severe | <1% of normal | Spontaneous bleeding predominantly in the joints or muscles but can occur anywhere, including life-threatening intracranial bleed |
Adapted with permission from Srivastava, A, Santagostino, E, Dougall, A, et al. WFH Guidelines for the Management of Hemophilia, 3rd edition.9 © 2020 World Federation of Hemophilia. Haemophilia © 2020 John Wiley & Sons Ltd.