Transfusion recommendations based on sickle cell genotype, hemoglobin, and surgical risk classification
| Sickle cell genotype . | Hemoglobin (g/dL) . | Surgical risk . | Transfusion recommendation . |
|---|---|---|---|
| HbSS or HbSβ0- thalassemia | <9 | Low or moderate | Simple transfusion, partial exchange, or RCE |
| HbSS or HbSβ0- thalassemia | >9 | Low or moderate | Partial exchange or RCE |
| HbSC, HbSβ+-thalassemia, and HbSS on hydroxyurea and elevated HbF without severe phenotype* | >9 | Low | No transfusion |
| HbSC or HbSβ+- thalassemia | >9 | Moderate | Partial exchange or RCE |
| All genotypes | — | High | RCE |
| Sickle cell genotype . | Hemoglobin (g/dL) . | Surgical risk . | Transfusion recommendation . |
|---|---|---|---|
| HbSS or HbSβ0- thalassemia | <9 | Low or moderate | Simple transfusion, partial exchange, or RCE |
| HbSS or HbSβ0- thalassemia | >9 | Low or moderate | Partial exchange or RCE |
| HbSC, HbSβ+-thalassemia, and HbSS on hydroxyurea and elevated HbF without severe phenotype* | >9 | Low | No transfusion |
| HbSC or HbSβ+- thalassemia | >9 | Moderate | Partial exchange or RCE |
| All genotypes | — | High | RCE |
Severe phenotype is defined as having a history of stroke, recurrent acute chest syndrome, or prior severe surgical complications.
HbSC, hemoglobin SC disease.