Key features differentiating pregnancy-associated and pregnancy-related TMAs
| Characteristic . | Incidence/pregnancies . | Thrombocytopenia . | HBP . | Renal impairment . | Neurologic features . | ADAMT-13 activity, IU/dL . |
|---|---|---|---|---|---|---|
| Preeclampsia | 1/20 | +++ | +++ | +/− | ++ | >20 |
| HELLP | 1/1000 | ++++ | + | +/− | +/− | >20 |
| TTP | 1/200,000 | +++ | + | + | +++ | <10 |
| CM-HUS | 1/25,000 | +++ | ++ | +++ | + | >20 |
| Characteristic . | Incidence/pregnancies . | Thrombocytopenia . | HBP . | Renal impairment . | Neurologic features . | ADAMT-13 activity, IU/dL . |
|---|---|---|---|---|---|---|
| Preeclampsia | 1/20 | +++ | +++ | +/− | ++ | >20 |
| HELLP | 1/1000 | ++++ | + | +/− | +/− | >20 |
| TTP | 1/200,000 | +++ | + | + | +++ | <10 |
| CM-HUS | 1/25,000 | +++ | ++ | +++ | + | >20 |
Note: the degree of involvement is demonstrated by an increasing number of +.
Table adapted from Scully.9
HBP, hypertension.