Hematologic parameters
| Parameter . | Control . | ST3Gal1MK−/− . | Jak3−/− . | DKO ST3Gal1MK−/−/Jak3−/− . |
|---|---|---|---|---|
| Peripheral blood counts (n = 7-14) | ||||
| RBC (109/mL) | 7.85 ± 0.19 | 7.94 ± 0.18 | 8.02 ± 0.29 | 7.45 ± 0.16 |
| WBC (106/mL) | 6.92 ± 0.59 | 6.95 ± 0.23 | 2.56 ± 0.45** | 3.11 ± 0.44*** |
| Platelet (109/mL) | 1.01 ± 0.04 | 0.50 ± 0.04**** | 1.10 ± 0.06 | 0.87 ± 0.06 |
| Platelet parameters (n = 7-14) | ||||
| MPV, fL | 6.75 ± 0.04 | 7.16 ± 0.08*** | 6.75 ± 0.07 | 7.23 ± 0.08**** |
| IPF, % | 0.20 ± 0.03 | 0.41 ± 0.06* | 0.20 ± 0.06 | 0.47 ± 0.06** |
| BM cell count (n = 5) | ||||
| MK, mm2 | 56 ± 5 | 53 ± 10 | 69 ± 2 | 66 ± 4 |
| LSK, % of BM | 0.29 ± 0.05 | 0.27 ± 0.08 | — | — |
| LK, % of BM | 1.23 ± 0.10 | 1.03 ± 0.10 | — | — |
| PreMegE, % of BM | 0.09 ± 0.01 | 0.11 ± 0.01 | — | — |
| MkP, % of BM | 0.068 ± 0.007 | 0.080 ± 0.008 | — | — |
| BM supernatant (n = 4) | ||||
| IFN-α, pg/mL | 0.066 ± 0.08 | 0.054 ± 0.03 | — | — |
| IFN-β, pg/mL | 1.52 ± 0.36 | 1.86 ± 0.36 | — | — |
| Parameter . | Control . | ST3Gal1MK−/− . | Jak3−/− . | DKO ST3Gal1MK−/−/Jak3−/− . |
|---|---|---|---|---|
| Peripheral blood counts (n = 7-14) | ||||
| RBC (109/mL) | 7.85 ± 0.19 | 7.94 ± 0.18 | 8.02 ± 0.29 | 7.45 ± 0.16 |
| WBC (106/mL) | 6.92 ± 0.59 | 6.95 ± 0.23 | 2.56 ± 0.45** | 3.11 ± 0.44*** |
| Platelet (109/mL) | 1.01 ± 0.04 | 0.50 ± 0.04**** | 1.10 ± 0.06 | 0.87 ± 0.06 |
| Platelet parameters (n = 7-14) | ||||
| MPV, fL | 6.75 ± 0.04 | 7.16 ± 0.08*** | 6.75 ± 0.07 | 7.23 ± 0.08**** |
| IPF, % | 0.20 ± 0.03 | 0.41 ± 0.06* | 0.20 ± 0.06 | 0.47 ± 0.06** |
| BM cell count (n = 5) | ||||
| MK, mm2 | 56 ± 5 | 53 ± 10 | 69 ± 2 | 66 ± 4 |
| LSK, % of BM | 0.29 ± 0.05 | 0.27 ± 0.08 | — | — |
| LK, % of BM | 1.23 ± 0.10 | 1.03 ± 0.10 | — | — |
| PreMegE, % of BM | 0.09 ± 0.01 | 0.11 ± 0.01 | — | — |
| MkP, % of BM | 0.068 ± 0.007 | 0.080 ± 0.008 | — | — |
| BM supernatant (n = 4) | ||||
| IFN-α, pg/mL | 0.066 ± 0.08 | 0.054 ± 0.03 | — | — |
| IFN-β, pg/mL | 1.52 ± 0.36 | 1.86 ± 0.36 | — | — |
Statistical analysis, 1-way analysis of variance; indicated notation is vs controls. Only significant changes are annotated. *P < .05, **P < .01, ****P < .0001.