Univariable and multivariable analysis of OS
| . | Univariable model . | Multivariable model . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age, 5-y increase | 1.18 (1.07-1.29) | .0005 | 1.18 (1.07-1.30) | .0007 |
| Female vs male | 0.89 (0.62-1.28) | .53 | — | — |
| Rai stage at diagnosis, 1 unit increase | 1.50 (1.27-1.77) | <.0001 | 1.32 (1.11-1.57) | .0015 |
| Concomitant moAB vs none | 0.90 (0.60-1.37) | .63 | — | — |
| Previously treated vs TN | 4.40 (1.94-10.0) | .0004 | 3.47 (1.51-7.95) | .0033 |
| ECOG PS score vs 0 | ||||
| 1 | 2.66 (1.76-4.02) | <.0001 | 2.11 (1.38-3.22) | .0007 |
| 2 | 7.13 (3.63-14.02) | <.0001 | 5.03 (2.52-10.04) | <.0001 |
| Hemoglobin, 1 unit increase | 0.82 (0.76-0.89) | <.0001 | — | — |
| Platelets, 50 unit increase | 0.78 (0.68-0.90) | .0004 | — | — |
| WBC count, twofold increase | 0.94 (0.86-1.02) | .12 | 0.92 (0.85-1.00) | .05 |
| LDH ≥ULN vs ≤ULN | 1.86 (1.31-2.64) | .0005 | 1.59 (1.10-2.30) | .01 |
| FISH del(11q) vs no del(11q) | 0.98 (0.69-1.39) | .91 | — | — |
| FISH trisomy 12 vs no trisomy 12 | 1.42 (0.98-2.05) | .07 | — | — |
| FISH del(13q) vs no del(13q) | 1.14 (0.82-1.57) | .44 | — | — |
| FISH del(17p) vs no del(17p) | 1.97 (1.42-2.72) | <.0001 | — | — |
| IGHV unmutated vs mutated | 1.38 (0.70-2.73) | .35 | — | — |
| Karyotypic complexity, 1 unit increase | 1.09 (1.06-1.13) | <.0001 | 1.09 (1.05-1.12) | <.0001 |
| Presence of structural abnormality vs none | 2.01 (1.36-2.98) | .0005 | — | — |
| . | Univariable model . | Multivariable model . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age, 5-y increase | 1.18 (1.07-1.29) | .0005 | 1.18 (1.07-1.30) | .0007 |
| Female vs male | 0.89 (0.62-1.28) | .53 | — | — |
| Rai stage at diagnosis, 1 unit increase | 1.50 (1.27-1.77) | <.0001 | 1.32 (1.11-1.57) | .0015 |
| Concomitant moAB vs none | 0.90 (0.60-1.37) | .63 | — | — |
| Previously treated vs TN | 4.40 (1.94-10.0) | .0004 | 3.47 (1.51-7.95) | .0033 |
| ECOG PS score vs 0 | ||||
| 1 | 2.66 (1.76-4.02) | <.0001 | 2.11 (1.38-3.22) | .0007 |
| 2 | 7.13 (3.63-14.02) | <.0001 | 5.03 (2.52-10.04) | <.0001 |
| Hemoglobin, 1 unit increase | 0.82 (0.76-0.89) | <.0001 | — | — |
| Platelets, 50 unit increase | 0.78 (0.68-0.90) | .0004 | — | — |
| WBC count, twofold increase | 0.94 (0.86-1.02) | .12 | 0.92 (0.85-1.00) | .05 |
| LDH ≥ULN vs ≤ULN | 1.86 (1.31-2.64) | .0005 | 1.59 (1.10-2.30) | .01 |
| FISH del(11q) vs no del(11q) | 0.98 (0.69-1.39) | .91 | — | — |
| FISH trisomy 12 vs no trisomy 12 | 1.42 (0.98-2.05) | .07 | — | — |
| FISH del(13q) vs no del(13q) | 1.14 (0.82-1.57) | .44 | — | — |
| FISH del(17p) vs no del(17p) | 1.97 (1.42-2.72) | <.0001 | — | — |
| IGHV unmutated vs mutated | 1.38 (0.70-2.73) | .35 | — | — |
| Karyotypic complexity, 1 unit increase | 1.09 (1.06-1.13) | <.0001 | 1.09 (1.05-1.12) | <.0001 |
| Presence of structural abnormality vs none | 2.01 (1.36-2.98) | .0005 | — | — |
del(11q), deletion of 11q; del(13q), deletion of 13q; ULN, upper limit of normal.